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Synthesis, Characterization, and Biological Activity of Organotin(IV) Complexes with Schiff Bases

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Abstract

The synthesized Schiff base ligands H2L1, N,N'-bis(2-hydroxybenzylidene)1,2-diaminobenzene, and H2L2, N,N'-bis(2-hydroxybenzylidene)hydrazine, reacted with Alk2SnCl2 to give organotin(IV) complexes 1–10. The products were characterized by elemental analysis, FTIR, 1H and 13C NMR, and mass spectrometry. All organotin(IV) derivatives with [O,N,O] donor ligands retained their 5-coordinated geometry in solid state and solutions. Most of synthesized complexes exhibited significant antibacterial activity. Cytotoxicity was also tested by using the brine shrimp (Artemia salina) lethality bioassay.

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Authors and Affiliations

  1. Department of Chemistry, IMCG (PG), F-7/2, Islamabad, Pakistan

    S. Nazneen

  2. Department of Chemistry, Quaid-i-Azam University, Islamabad, 45320, Pakistan

    S. Ali & S. Shahzadi

  3. Department of Chemistry, University of Sargodha, Lyallpur Campus, Faisalabad, Pakistan

    S. Shahzadi

  4. Department of Chemistry, Kohat University of Science and Technology, Kohat, KPK, 26000, Pakistan

    S. Shujah

Authors
  1. S. Nazneen
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  2. S. Ali
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  3. S. Shahzadi
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  4. S. Shujah
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Corresponding authors

Correspondence to S. Ali or S. Shahzadi.

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The text was submitted by the authors in English.

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Nazneen, S., Ali, S., Shahzadi, S. et al. Synthesis, Characterization, and Biological Activity of Organotin(IV) Complexes with Schiff Bases. Russ J Gen Chem 87, 2970–2978 (2017). https://doi.org/10.1134/S1070363217120404

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  • DOI: https://doi.org/10.1134/S1070363217120404

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