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Synthesis and some reactions of novel (4Z)-4-{[1-(3-chlorophenyl)-3-(4-methoxyphenyl)-1H-pyrazol-4-yl]methylene}-2-hydrazinyl-1-phenyl-1H-imidazol-5(4H)-ones

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Abstract

Some novel (4Z)-2-[(E)-2-arylidenehydrazinyl]-4-{[1-(3-chlorophenyl)-3-(4-methoxyphenyl)-1H-pyrazol-4-yl]methylene}-1-phenyl-1H-imidazol-5(4H)-ones have been synthesized in a one-pot threecomponent cyclocondensation of pyrazole-4-carbaldehyde derivative with glycine and different isothiocyanate derivatives. The structures of the newly synthesized compounds were characterized by analytical and spectral data.

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Authors and Affiliations

  1. Pharmaceutical Chemistry Department, Drug Exploration & Development Chair (DEDC), College of Pharmacy, King Saud University, Riyadh, 11451, Saudi Arabia

    N. M. Khalifa & M. A. Al-Omar

  2. Department of Therapeutical Chemistry, Pharmaceutical and Drug Industries Division, National Research Centre, Dokki, Cairo, 12622, Egypt

    N. M. Khalifa

  3. Department of Pharmaceutical Chemistry, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, 11754, Egypt

    E. S. Nossier

Authors
  1. N. M. Khalifa
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  2. M. A. Al-Omar
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  3. E. S. Nossier
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Correspondence to N. M. Khalifa.

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Khalifa, N.M., Al-Omar, M.A. & Nossier, E.S. Synthesis and some reactions of novel (4Z)-4-{[1-(3-chlorophenyl)-3-(4-methoxyphenyl)-1H-pyrazol-4-yl]methylene}-2-hydrazinyl-1-phenyl-1H-imidazol-5(4H)-ones. Russ J Gen Chem 87, 1621–1626 (2017). https://doi.org/10.1134/S1070363217070283

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  • DOI: https://doi.org/10.1134/S1070363217070283

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