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Synthesis and characterization of some novel 7-(aryl)-3-phenyl-6-(1H-tetrazol-5-yl)-5H-thiazolo[3,2-a]pyrimidin-5-one derivatives

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Abstract

A series of novel tetrazole derivatives containing fused thiazolo[3,2-a]pyrimidines were synthesized in a one-pot three-component reaction of 7-(aryl)-5-oxo-3-phenyl-5H-thiazolo[3,2-a]pyrimidine-6-carbonitriles with sodium azide and ammonium chloride.

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Authors and Affiliations

  1. Pharmaceutical Chemistry Department, Drug Exploration & Development Chair (DEDC), College of Pharmacy, King Saud University, Riyadh, 11451, Saudi Arabia

    N. M. Khalifa, M. A. Al-Omar & A. E. Amr

  2. Department of Therapeutical Chemistry, Pharmaceutical and Drug Industries Division, National Research Centre, Dokki, 12622, Cairo, Egypt

    N. M. Khalifa

  3. Applied Organic Chemistry Department, National Research Centre, Dokki, 12622, Cairo, Egypt

    A. E. Amr

Authors
  1. N. M. Khalifa
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  2. M. A. Al-Omar
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  3. A. E. Amr
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Correspondence to N. M. Khalifa.

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The text was submitted by the authors in English.

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Khalifa, N.M., Al-Omar, M.A. & Amr, A.E. Synthesis and characterization of some novel 7-(aryl)-3-phenyl-6-(1H-tetrazol-5-yl)-5H-thiazolo[3,2-a]pyrimidin-5-one derivatives. Russ J Gen Chem 87, 1618–1620 (2017). https://doi.org/10.1134/S1070363217070271

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  • DOI: https://doi.org/10.1134/S1070363217070271

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