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Synthesis of new daunorubicin N-derivatives by one-step reductive amination

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Abstract

One-step reductive amination of aromatic aldehydes using an anthracycline antibiotic daunorubicin resulted in the preparation of its new N-derivatives, which are of interest as potential antitumor drugs.

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Authors and Affiliations

  1. Nesmeyanov Institute of Organoelemental Compounds, Russian Academy of Sciences, ul. Vavilova 28, Moscow, 119991, Russia

    O. I. Artyushin, E. V. Sharova, N. M. Vinogradova, G. K. Genkina, A. A. Moiseeva, A. A. Khodak & V. K. Brel

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  1. O. I. Artyushin
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  2. E. V. Sharova
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  3. N. M. Vinogradova
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  4. G. K. Genkina
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  5. A. A. Moiseeva
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  6. A. A. Khodak
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  7. V. K. Brel
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Corresponding author

Correspondence to V. K. Brel.

Additional information

Original Russian Text © O.I. Artyushin, E.V. Sharova, N.M. Vinogradova, G.K. Genkina, A.A. Moiseeva, A.A. Khodak, V.K. Brel, 2017, published in Zhurnal Obshchei Khimii, 2017, Vol. 87, No. 6, pp. 1051–1054.

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Artyushin, O.I., Sharova, E.V., Vinogradova, N.M. et al. Synthesis of new daunorubicin N-derivatives by one-step reductive amination. Russ J Gen Chem 87, 1323–1326 (2017). https://doi.org/10.1134/S1070363217060330

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  • DOI: https://doi.org/10.1134/S1070363217060330

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