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Synthesis of 3-(4-fluorophenyl)-3-(4-methoxyphenyl)-1-propanarylamines and their antibacterial activity

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Abstract

Condensation of 3-(4-fluorophenyl)-3-(4-methoxyphenyl)-1-propanamine with aromatic aldehydes and ketones followed by the reduction of the obtained azomethines with NaBH4 afforded secondary propanaryl -amines, whose oxalates and hydrochlorides possess high antibacterial activity.

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References

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Authors and Affiliations

  1. Mnjoyan Institute of Fine Organic Chemistry, Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of Armenia, Azatutyan pr. 26, Yerevan, 0014, Armenia

    N. S. Arutyunyan, L. A. Akopyan, R. A. Akopyan, G. M. Stepanyan & G. A. Gevorgyan

  2. Molecular Structure Research Center, National Academy of Sciences of the Republic of Armenia, Yerevan, Armenia

    G. A. Panosyan

Authors
  1. N. S. Arutyunyan
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  2. L. A. Akopyan
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  3. R. A. Akopyan
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  4. G. M. Stepanyan
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  5. G. A. Panosyan
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  6. G. A. Gevorgyan
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Corresponding author

Correspondence to G. A. Gevorgyan.

Additional information

Original Russian Text © N.S. Arutyunyan, L.A. Akopyan, R.A. Akopyan, G.M. Stepanyan, G.A. Panosyan, G.A. Gevorgyan, 2017, published in Zhurnal Obshchei Khimii, 2017, Vol. 87, No. 6, pp. 1028–1032.

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Arutyunyan, N.S., Akopyan, L.A., Akopyan, R.A. et al. Synthesis of 3-(4-fluorophenyl)-3-(4-methoxyphenyl)-1-propanarylamines and their antibacterial activity. Russ J Gen Chem 87, 1300–1304 (2017). https://doi.org/10.1134/S1070363217060275

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  • DOI: https://doi.org/10.1134/S1070363217060275

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