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Synthesis and molecular docking studies of novel 2-phenyl-4-{4-[(1-phenyl-1H-1,2,3-triazol-4-yl)methoxy]benzylidene}oxazol-5(4H)-one derivatives

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Abstract

2-Phenyl-4-{4-[(1-phenyl-1H-1,2,3-triazol-4-yl)methoxy]benzylidene}oxazol-5(4H)-one derivatives were synthesized by click chemistry reactions. Exploration of molecular interaction of the obtained compounds, performed through molecular docking studies with α-glucosidase, revealed the high docking scores (LibDock) in the range of 135.056–126.164 as compared to acarbose (136.345).

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Authors and Affiliations

  1. Department of Chemistry, University College for Women, Osmania University, Hyderabad, Telangana, 500007, India

    B. Sathish Kumar & P. V. Anantha Lakshmi

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  1. B. Sathish Kumar
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  2. P. V. Anantha Lakshmi
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Correspondence to P. V. Anantha Lakshmi.

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Sathish Kumar, B., Anantha Lakshmi, P.V. Synthesis and molecular docking studies of novel 2-phenyl-4-{4-[(1-phenyl-1H-1,2,3-triazol-4-yl)methoxy]benzylidene}oxazol-5(4H)-one derivatives. Russ J Gen Chem 87, 1057–1063 (2017). https://doi.org/10.1134/S1070363217050279

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  • DOI: https://doi.org/10.1134/S1070363217050279

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