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Synthesis of N-methylpiperidin-4-one derivatives and evaluation of their anti-endometrial cancer activity

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Abstract

Four novel N-methylpiperidin-4-one derivatives were synthesized and characterized by IR, 1H NMR, HRMS, and single crystal X-ray crystallography. The anticancer activity of these compounds was studied on five human endometrial cancer cell lines (RL-95-2, HEC-1A, HEC-1B, AN3CN and HECCL-1). Efficient antitumor effect was found for the 3,5-difluorophenyl- and 3-cyanophenyl-substituted derivatives.

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Authors and Affiliations

  1. Department of Human Anatomy, Bengbu Medical College, Bengbu, Anhui, China

    Gui-Hua Lai

  2. Department of Chemistry, Bengbu Medical College, Bengbu, Anhui, China

    Yu-Lan Huang

  3. Department of Rheumatology, The Sixth Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China

    Bai-Yu Zhang

Authors
  1. Gui-Hua Lai
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  2. Yu-Lan Huang
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  3. Bai-Yu Zhang
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Correspondence to Bai-Yu Zhang.

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The text was submitted by the authors in English.

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Lai, GH., Huang, YL. & Zhang, BY. Synthesis of N-methylpiperidin-4-one derivatives and evaluation of their anti-endometrial cancer activity. Russ J Gen Chem 87, 1053–1056 (2017). https://doi.org/10.1134/S1070363217050267

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  • DOI: https://doi.org/10.1134/S1070363217050267

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