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Synthesis of podands modified with thiosemicarbazide and fluoroalkyl(hydroxy)pyrazoline fragments

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Abstract

1,8-Bis(diisothiosemicarbazido)-3,6-dioxaoctane have been synthesized by subsequent treatment of 2,2′-(ethylenedioxy)bisethylamine with carbon disulfide, sodium chloroacetate, and hydrazine hydrate. 1,8-Bis- (diisothiosemicarbazido)-3,6-dioxaoctane has reacted with lithium 1,1-difluoropenta-2,4-dionate in glacial acetic acid to yield 1,8-bis[5R*,5′R*(5-hydroxy-5-difluoromethyl-4,5-dihydro-3-methyl-1H-pyrazol-1-yl)-1-carbothioamido]-3,6-dioxaoctane. The molecular and crystal structure of the product has been determined by X-ray diffraction analysis.

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Authors and Affiliations

  1. Postovskii Institute of Organic Synthesis, Ural Brach, Russian Academy of Sciences, ul. S. Kovalevskoi/Akademicheskaya 20/22, Yekaterinburg, 620990, Russia

    V. I. Filyakova, P. A. Slepukhin, N. S. Boltacheva, E. B. Letova & V. N. Charushin

Authors
  1. V. I. Filyakova
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  2. P. A. Slepukhin
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  3. N. S. Boltacheva
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  4. E. B. Letova
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  5. V. N. Charushin
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Corresponding author

Correspondence to V. I. Filyakova.

Additional information

Original Russian Text © V.I. Filyakova, P.A. Slepukhin, N.S. Boltacheva, E.B. Letova, V.N. Charushin, 2017, published in Zhurnal Obshchei Khimii, 2017, Vol. 87, No. 5, pp. 766–771.

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Filyakova, V.I., Slepukhin, P.A., Boltacheva, N.S. et al. Synthesis of podands modified with thiosemicarbazide and fluoroalkyl(hydroxy)pyrazoline fragments. Russ J Gen Chem 87, 957–962 (2017). https://doi.org/10.1134/S1070363217050115

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  • DOI: https://doi.org/10.1134/S1070363217050115

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