Russian Journal of General Chemistry

, Volume 87, Issue 4, pp 837–841 | Cite as

An efficient reduction of nitro and bromine naphthalene derivatives

  • J. Dong
  • Q. Zhang
  • G. Huang
  • Q. MengEmail author
  • S. Li


Reduction of 1,5-dimethoxy-4-nitronaphthalene by hydrazine hydrate was optimized in the course of current study. Influence of metals, temperature and solvents upon the process was tested. Yield of the reaction was the highest in the presence of Zn powder in DMF. Moderate heating made the process slightly more efficient than that at room temperature, whereas high temperature led to a decreased yield. The current approach made it possible to exclude high pressure and diminish experimental costs.


nitro naphthalenes reduction naphthylamines hydrazine hydrate zinc powder 


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© Pleiades Publishing, Ltd. 2017

Authors and Affiliations

  1. 1.School of PharmacyShanghai Jiaotong UniversityShanghaiChina

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