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Synthesis and antibacterial activity of novel pyrano[2,3-d]pyrimidine-4-one–3-phenylisoxazole hybrids

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Abstract

A series of ethyl 2,7-dimethyl-4-oxo-5-phenyl-3-[(3-phenylisoxazol-5-yl)methyl]-3,5-dihydro-4H-pyrano[2,3-d]pyrimidine-6-carboxylates was synthesized and screened for antibacterial activity against Gram positive and Gram negative bacterial species. All new compounds were characterized by 1H, 13C NMR, IR, and mass spectra. The results of the antibacterial study indicated that all compounds exhibited good to excellent antibacterial activity.

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Authors and Affiliations

  1. Department of Chemistry, University College for Women, Osmania University, Hyderabad, Telangana, 500007, India

    B. S. Kumar & P. V. A. Lakshmi

  2. Department of Botany, University College of Science, Osmania University, Hyderabad, Telangana, 500007, India

    B. S. Veena & E. Sujatha

Authors
  1. B. S. Kumar
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  2. P. V. A. Lakshmi
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  3. B. S. Veena
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  4. E. Sujatha
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Correspondence to P. V. A. Lakshmi.

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The text was submitted by the authors in English.

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Kumar, B.S., Lakshmi, P.V.A., Veena, B.S. et al. Synthesis and antibacterial activity of novel pyrano[2,3-d]pyrimidine-4-one–3-phenylisoxazole hybrids. Russ J Gen Chem 87, 829–836 (2017). https://doi.org/10.1134/S1070363217040260

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  • DOI: https://doi.org/10.1134/S1070363217040260

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