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Synthesis and biological evaluation of 1,3,4-oxadiazole fused pyridine derivatives as antibacterial and antifungal agents

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Abstract

A series of novel 1,3,4-oxadiazole fused pyridine derivatives were synthesized 11a–11f and their structures confirmed by IR, 1H NMR and Mass spectral data. The compounds were evaluated for their antibacterial and antifungal activities against Gram negative and positive bacterial strains including Escherichia coli (MTCC 443), K. Pneumoniae (MTCC 109), S. Aureus (MTCC 96), B. Subtilis (MTCC 441) and Sclerotium rolfsii, Macrophomina phaseolina. Compounds 11d, 11e, and 11f demonstrated high antibacterial activity.

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References

  1. Patel, N.B. and Patel, H.R., Arab. J. Chem., 2012, vol. 5, p. 81. doi 10.1016/j.arabjc.2010.07.028

    Article  CAS  Google Scholar 

  2. Liu, Y.X., Wei, D.G., Zhu, Y.R., Liu, S.H., Zhang, Y.L., Zhao, Q.Q., Cai, B.L., Li, Y.H., Song, H.B., Liu, Y., Wang, Y., Huang, R.Q., and Wang, Q.M., J. Agric. Food Chem., 2008, vol. 56, p. 204. doi 10.1021/jf072851x

    Article  CAS  Google Scholar 

  3. Kang, S.H., Song, B.A., Wu, J., He, M., Hu, D.Y., Jin, L.H., Zeng, S., Xue, W., and Yang, S., Eur. J. Med. Chem., 2013, vol. 67, p. 14. doi 10.1016/j.ejmech.2013.06.023

    Article  CAS  Google Scholar 

  4. Perrier, V., Wallace, A.C., Kaneko, K., Safar, J., Prusiner, S.B., and Cohen, F.E., Proc. Natl. Acad. Sci. U.S.A., 2000, vol. 97, p. 6073.

    Article  CAS  Google Scholar 

  5. Chen, H., Zhang, W., Tam, R., and Raney, A.K., PCT Int. Appl., WO 2005058315 A1 20050630, 2005.

  6. Levy, S.B., Alekshun, M.N., Podlogar, B.L., Ohemeng, K., Verma, A.K., Warchol, T., Bhatia, B., Bowser, T., and Grier, M., USA Patent Appl., 2005124678 A1 20050609, 2005.

  7. Anderson, D.R., Stehle, N.W., Kolodziej, S.A., and Reinhard, E., J. PCT Int. Appl., WO 2004055015 A1 20040701, 2004.

  8. Prasanthi, G., Prasad, K.V., and Bharathi, K., Eur. J. Med. Chem., 2014, vol. 73, p. 97. doi 10.1016/j.ejmech.2013.12.001

    Article  CAS  Google Scholar 

  9. Brun, P., Dean, A., Di Marco, V., Surajit, P., Castagliuolo, I., Carta, D., and Ferlin, M.G., Eur. J. Med. Chem., 2013, vol. 62, p. 486. doi 10.1016/j.ejmech.2013.01.024

    Article  CAS  Google Scholar 

  10. Joule, J.A. and Mills, K., Heterocyclic Chemistry, Blackwell Publishing, 2000, 4th ed.

    Google Scholar 

  11. Storr, S.J., Royle, L., Chapman, C.J., Hamid, U.M.A., Robertson, J.F., Murray, A., Dwek, R.A., and Rudd, P.M., Glycobiology, 2008, vol. 18, p. 456. doi 10.1093/glycob/cwn022

    Article  CAS  Google Scholar 

  12. Rigo, B. and Couturier, D., J. Heterocyclic Chem., 1985, vol. 22, p. 287. doi 10.1002/jhet.5570220209

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Chemistry, University College of Technology, Osmania University, Hyderabad, 500007, India

    N. J. P. Subhashini, B. Bhadraiah & P. Janaki

  2. Chemistry Services, GVK Biosciences Pvt.Ltd, IDA Nacharam, Hyderabad, 500076, India

    B. Bhadraiah

Authors
  1. N. J. P. Subhashini
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  2. B. Bhadraiah
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  3. P. Janaki
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Correspondence to N. J. P. Subhashini.

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Subhashini, N.J.P., Bhadraiah, B. & Janaki, P. Synthesis and biological evaluation of 1,3,4-oxadiazole fused pyridine derivatives as antibacterial and antifungal agents. Russ J Gen Chem 87, 550–553 (2017). https://doi.org/10.1134/S1070363217030276

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  • DOI: https://doi.org/10.1134/S1070363217030276

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