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Nano isopolyoxomolybdate catalyzed Biginelli reaction for one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones and 3,4-dihydropyrimidin-2(1H)-thiones under solvent-free conditions

Russian Journal of General Chemistry volume 86, pages 2870–2876 (2016)Cite this article

Abstract

The Biginelli reaction of β-ketoesters with aryl aldehyde and urea or thiourea in the presence of a Keplerate type giant nanoporous isopolyoxomolybdate, (NH4)42[Mo VI72 Mo V60 O372(CH3COO)30(H2O)72], presented as {Mo132}, as an efficient catalyst under solvent free conditions is reported. The catalyst was synthesized according to the earlier published procedure using inexpensive and readily available starting materials. The catalyst could be recovered and reused efficiently in six cycles. Other beneficial features of this new synthetic approach include short reaction time, high yields, clean reaction profiles, and a simple work-up procedure.

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Authors and Affiliations

  1. Young Researchers and Elite Club, Mashhad Branch, Islamic Azad University, Mashhad, Iran

    A. Nakhaei & S. Yadegarian

  2. Department of Chemistry, Mashhad Branch, Islamic Azad University, Mashhad, Iran

    A. Davoodnia

Authors
  1. A. Nakhaei
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  2. A. Davoodnia
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  3. S. Yadegarian
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Correspondence to A. Nakhaei.

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Nakhaei, A., Davoodnia, A. & Yadegarian, S. Nano isopolyoxomolybdate catalyzed Biginelli reaction for one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones and 3,4-dihydropyrimidin-2(1H)-thiones under solvent-free conditions. Russ J Gen Chem 86, 2870–2876 (2016). https://doi.org/10.1134/S1070363216120537

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  • DOI: https://doi.org/10.1134/S1070363216120537

Keywords

  • giant nanoporous isopolyoxomolybdate
  • keplerate
  • {Mo132}
  • Biginelli reaction
  • 3,4-dihydropyrimidin-2(1H)-ones
  • 3,4-dihydropyrimidin-2(1H)-thiones
  • solvent-free