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Diastereotopic derivatives of chiral alkoxyisoindolinones

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Abstract

A method for synthesis of 2,3-substituted 3-hydroxyisoindolin-1-one acyl derivatives, modified reactivators of tumor suppressor protein p53, was developed; these compounds were synthesized and characterized. It was shown that diastereomeric esters of Boc-N-protected amino acids, unlike esters with a free amino group, can be preparatively isolated by flash chromatography using achiral media.

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Authors and Affiliations

  1. St. Petersburg State Institute of Technology (Technical University), Moskovskii pr. 26, St. Petersburg, 190013, Russia

    T. A. Grigoreva, A. V. Garabadzhiu & V. G. Tribulovich

Authors
  1. T. A. Grigoreva
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  2. A. V. Garabadzhiu
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  3. V. G. Tribulovich
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Correspondence to T. A. Grigoreva.

Additional information

Original Russian Text © T.A. Grigoreva, A.V. Garabadzhiu, V.G. Tribulovich, 2016, published in Zhurnal Obshchei Khimii, 2016, Vol. 86, No. 11, pp. 1811–1818.

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Grigoreva, T.A., Garabadzhiu, A.V. & Tribulovich, V.G. Diastereotopic derivatives of chiral alkoxyisoindolinones. Russ J Gen Chem 86, 2454–2461 (2016). https://doi.org/10.1134/S1070363216110098

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  • DOI: https://doi.org/10.1134/S1070363216110098

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