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Microwave assisted synthesis of substituted (Z)-2-{[1-phenyl-3-(thiophen-2-yl)-1H-pyrazol- 4-yl]methylene}benzofuran-3(2H)-ones and their antimicrobial activity

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Abstract

Aurones, pyrazole and thiophene scaffolds are known for their potential antimicrobial activity. Herein, we have synthesized hybrid compounds containing three substituted (Z)-2-{[1-phenyl-3-(thiophen-2-yl)- 1H-pyrazol-4-yl]methylene}benzofuran-3(2H)-ones that had been produced from substituted (E)-1-(2-hydroxyphenyl)- 3-[1-phenyl-3-(thiophen-2-yl)-1H-pyrazol-4-yl]prop-2-en-1-ones in high yields. All synthesized compounds were tested in vitro for their antimicrobial activity. Several of those demonstrated promising activity against some fungal and bacterial strains.

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Authors and Affiliations

  1. Green and Medical Chemistry Laboratory, Department of Chemistry, Osmania University, Hyderabad, 500007, India

    D. Ashok, M. Ziauddin, B. Vijaya Lakshmi & M. Sarasija

  2. Department of Pharmaceutical Sciences, University College of Technology, Osmania University, Hyderabad, 500007, India

    M. Ziauddin

Authors
  1. D. Ashok
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  2. M. Ziauddin
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  3. B. Vijaya Lakshmi
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  4. M. Sarasija
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Correspondence to D. Ashok.

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The text was submitted by the authors in English.

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Ashok, D., Ziauddin, M., Lakshmi, B.V. et al. Microwave assisted synthesis of substituted (Z)-2-{[1-phenyl-3-(thiophen-2-yl)-1H-pyrazol- 4-yl]methylene}benzofuran-3(2H)-ones and their antimicrobial activity. Russ J Gen Chem 86, 1753–1757 (2016). https://doi.org/10.1134/S1070363216070355

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  • DOI: https://doi.org/10.1134/S1070363216070355

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