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Synthesis and antimicrobial evaluation of tricyclic macrocycles containing a chalcone moiety

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Abstract

A series of new tricyclic macrocycles containing a chalcone moiety were synthesized from chalcones through alkylation using different dibromoalkanes. All the synthesized compounds were characterized by IR, 1H NMR, 13C NMR, and mass spectral data and evaluated for their in vitro antimicrobial activity.

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References

  1. DeLorbe, J.E., Clements, J.H., Whiddon, B.B., and Martin, S. F., ACS Med. Chem. Lett., 2010, vol. 1, p. 448. DOI: 10.1021/ml100142y.

    Article  CAS  Google Scholar 

  2. Madsen, C.M. and Clausen, M.H., Eur. J. Org. Chem., 2011, p. 3107. DOI: 10.1002/ejoc.201001715.

    Google Scholar 

  3. Halland, N., Blum, H., Buning C., Kohlmann, M., and Lindenschmidt, A., ACS Med. Chem. Lett., 2014, vol. 5, p. 193. DOI: 10.1021/ml4004556.

    Article  CAS  Google Scholar 

  4. Jefferson, E.A., Arakawa, S., Blyn, L.B., Miyaji, A., Osgood, S.A., Ranken, R., Risen, L.M., and Swayze, E.E., J. Med. Chem., 2002, vol. 45, p. 3430.

    Article  CAS  Google Scholar 

  5. Marsault, E. and Peterson, M.L., J. Med. Chem., 2011, vol. 54, p. 1961. DOI: 10.1021/jm1012374.

    Article  CAS  Google Scholar 

  6. Obniska, J., Zeic, A., and Zagorska, A., Acta Pol. Pharm., 2002, vol. 59, no. 3, p. 209. ISSN 0001-6837.

    CAS  Google Scholar 

  7. Mukherjee, S., Kumar, V., Prasad, A.K., Raj, H.G., Bracke, M.E., Olsen, C.E., Jain, S.C., and Parmar, V.S., Bioorg. Med. Chem., 2001, vol. 9, p. 337. DOI: 10.1016/S0968-0896(00)00249-2.

    Article  CAS  Google Scholar 

  8. Trivedi, J.C., Bariwal, J.B., Upadhyay, K.D., Naliapara, Y.T., Soshi, S.K., Pannecouque, C.C., De Clercq, E., and Shah, A.K., Tetrahedron Lett., 2007, vol. 48, p. 8472. DOI: 10.1016/j.tetlet.2007.09.175.

    Article  CAS  Google Scholar 

  9. Satyanarayana, M., Tiwari, P., Tripathi, B. K., Srivastava, A.K., and Pratap. R., Bioorg. Med. Chem., 2004, vol. 12, p. 883. DOI: 10.1016/j.bmc.2003.12.026.

    Article  CAS  Google Scholar 

  10. Go, M.L., Wu, X., and Liu, X.L., Curr. Med. Chem., 2005, vol. 12, p. 483.

    Article  CAS  Google Scholar 

  11. Hsieh, H.K., Tsao, L.T., Wang, J.P., and Lin, C.N., J. Pharm. Pharmacol., 2000, vol. 52, no. 2, p. 163. DOI: 10.1211/0022357001773814.

    Article  CAS  Google Scholar 

  12. Dongamanti, A., Aamate, V.K., Devulapally, M.G., Gundu, S., Kotni, M.K., Manga, V., Sridhar, B., and Prasad, E., Bioorg. Med. Chem.Lett., 2015, vol. 25, p. 898. DOI: 10.1016/j.bmcl.2014.12.066.

    Article  CAS  Google Scholar 

  13. Raval, A.A. and Shah, N.M., J. Org. Chem., 1956, vol. 21, p. 1408. DOI: 10.1021/jo01118a021.

    Article  CAS  Google Scholar 

  14. Rao, Y.K., Fang, S.H., and Tzeng, Y.M., Bioorg. Med. Chem., 2004, vol. 12, p. 2679. DOI: 10.1016/j.bmc.2004.03.014.

    Article  CAS  Google Scholar 

  15. Radha, K., Pritam, T., Han, Y.Y., Tara, M.K., Park, P.H., Youngwha, N., Eunyoung, L., Jeon, K.H., Cho, W.J., Heesung, C., Youngjoo, K., and Lee, E.S., Eur. J. Med. Chem., 2012, vol. 49, p. 219. DOI: 10.1016/j.ejmech.2012.01.015.

    Article  Google Scholar 

  16. Rina, M., Tapas, K.M., and Ashok K.M., Arkivoc, 2012, vol. 9, p. 95. DOI: 12-7621BP.

    Google Scholar 

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Authors and Affiliations

  1. Department of Chemistry, Osmania University, Hyderabad, 500007, India

    A. Dongamanti, V. K. Aamate, S. Gundu & M. G. Devulapally

Authors
  1. A. Dongamanti
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  2. V. K. Aamate
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  3. S. Gundu
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  4. M. G. Devulapally
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Correspondence to A. Dongamanti.

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The text was submitted by the authors in English.

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Dongamanti, A., Aamate, V.K., Gundu, S. et al. Synthesis and antimicrobial evaluation of tricyclic macrocycles containing a chalcone moiety. Russ J Gen Chem 86, 1705–1710 (2016). https://doi.org/10.1134/S1070363216070288

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  • DOI: https://doi.org/10.1134/S1070363216070288

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