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Synthesis of new 1,3-thiazole derivatives from 2(5)-hydroxyalkyl-1,3-thiazole-5(2)-carbaldehydes

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Abstract

Reactions of substituted 2-hydroxyalkyl-1,3-thiazole-5-carbaldehydes and 5-hydroxyalkyl-1,3-thiazole-2-carbaldehydes with phenylhydrazine, isoniazid, N-substituted rhodanines were performed as well as Biginelli reaction with acetoacetic ester and urea. As a result, new 1,3-thiazole derivatives were obtained. They are of interest as potential bioactive substances.

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Authors and Affiliations

  1. Institute of Bioorganic Chemistry and Petrochemistry, National Academy of Sciences of Ukraine, ul. Murmanskaya 1, Kyiv, 02660, Ukraine

    V. O. Sinenko, S. R. Slivchuk, S. G. Pil’o & V. S. Brovarets

  2. Litvinenko Institute of Physical Organic and Coal Chemistry, National Academy of Sciences of Ukraine, Kyiv, Ukraine

    G. F. Raenko

Authors
  1. V. O. Sinenko
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  2. S. R. Slivchuk
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  3. S. G. Pil’o
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  4. G. F. Raenko
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  5. V. S. Brovarets
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Corresponding author

Correspondence to V. S. Brovarets.

Additional information

Original Russian Text © V.O. Sinenko, S.R. Slivchuk, S.G. Pil’o, G.F. Raenko, V.S. Brovarets, 2016, published in Zhurnal Obshchei Khimii, 2016, Vol. 86, No. 7, pp. 1119–1125.

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Sinenko, V.O., Slivchuk, S.R., Pil’o, S.G. et al. Synthesis of new 1,3-thiazole derivatives from 2(5)-hydroxyalkyl-1,3-thiazole-5(2)-carbaldehydes. Russ J Gen Chem 86, 1597–1603 (2016). https://doi.org/10.1134/S1070363216070100

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  • DOI: https://doi.org/10.1134/S1070363216070100

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