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A novel method for the synthesis of maxacalcitol

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Abstract

Maxacalcitol (1), a kind of active vitamin D drugs, was prepared from pregnenolone acetate (2) using a novel synthetic method including the combination of five-step organic transformations and one-step biological transformation. The new protocol was shorter, milder, and simpler than the reported approaches. The unoptimized overall yield was 0.178%. The structure of all intermediates and final product was confirmed by 1H NMR, 13C NMR and MS techniques.

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Authors and Affiliations

  1. Laboratory of Synthesis and Catalysis, School of Life Sciences and Engineering, Southwest Jiaotong University, Chengdu, 610031, China

    W.-Q. Song, Y.-H. Wang, D.-N. Liu, W.-Z. Fang & Q. Lu

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  1. W.-Q. Song
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  2. Y.-H. Wang
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  3. D.-N. Liu
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  4. W.-Z. Fang
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  5. Q. Lu
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Correspondence to Q. Lu.

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The text was submitted by the authors in English.

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Song, WQ., Wang, YH., Liu, DN. et al. A novel method for the synthesis of maxacalcitol. Russ J Gen Chem 86, 173–177 (2016). https://doi.org/10.1134/S1070363216010278

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  • DOI: https://doi.org/10.1134/S1070363216010278

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