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Russian Journal of General Chemistry

, Volume 85, Issue 10, pp 2285–2290 | Cite as

Synthesis and reactivity of 3-(2,2-dimethylhydrazono)-5-R-cyclopentane-1,1,2,2-tetracarbonitriles

  • V. P. SheverdovEmail author
  • O. E. Nasakin
  • V. V. Davydova
  • V. N. Khrustalev
Article
  • 52 Downloads

Abstract

A new method of the synthesis of 3-(2,2-dimethylhydrazono)-5-R-1,1,2,2-tetracarbonitriles via oxidation of 3-(2,2-dimethylhydrazino)-5-R-1,1,2,2- tetracarbonitriles with diluted nitric acid was developed. High reactivity of 3-(2,2-dimethylhydrazono)-5-R-1,1,2,2-tetracarbonitriles caused by the presence of ethyl-1,1,2,2-tetracarbonitrile and N,N-dimethylhydrazone moieties allowed obtaining 2-methyl-5-R-3,4-dihydro-2Н-cyclopenta[e]1,2,4triazine-6,6,7,7-tetracarbonitriles, 3-amino-4-(2,2-dimethylhydrazono)-6-methyl-1,3а,4,5,6,6а- hexahydrocyclopenta[c]pyrrole-3а,6а-dicarbonitriles, and 3-(2,2-dimethylhydrazino)-5-methylcyclopent-2-ene-1,1,2-tricarbonitrile.

Keywords

oxidation ethyl-1,1,2,2-tetracarbonitrile moiety one-step methods reverse hyperconjugation antitumor activity 

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Copyright information

© Pleiades Publishing, Ltd. 2015

Authors and Affiliations

  • V. P. Sheverdov
    • 1
    Email author
  • O. E. Nasakin
    • 1
  • V. V. Davydova
    • 1
  • V. N. Khrustalev
    • 2
    • 3
  1. 1.Ulyanov Chuvash State UniversityCheboksaryRussia
  2. 2.Peoples’ Friendship University of RussiaMoscowRussia
  3. 3.Nesmeyanov Institute of Organoelemental CompoundsRussian Academy of SciencesMoscowRussia

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