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Aluminum hydrogen sulfate as a green catalyst for the solvent-free synthesis of pyrazolopyridines


Aluminum hydrogen sulfate turned out to be a mild, convenient, and efficient reagent for the conversion of substituted benzyl alcohols into pyrazolopyridines via condensation with 3-methyl-1H-pyrazole-5-amine and CH acid (malononitrile or indan-1,3-dione) at room temperature under solvent-free conditions with high yield, high purity, and short reaction time.

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Correspondence to M. Nikpassand.

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Nikpassand, M., Zare Fekri, L. Aluminum hydrogen sulfate as a green catalyst for the solvent-free synthesis of pyrazolopyridines. Russ J Gen Chem 85, 1179–1183 (2015).

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  • pyrazolopyridine
  • solvent free
  • aluminum hydrogen sulfate
  • green catalyst