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Amidoalkylation of phosphorous acid

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Abstract

A convenient approach to prepare N-protected α-aminophosphonic acids (phospho-isosteres of natural amino acids) via amidoalkylation of phosphorous acid in a mixture of acetic anhydride and acetyl chloride upon cooling has been developed.

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Authors and Affiliations

  1. Institute of Physiologically Active Compounds, Russian Academy of Sciences, Severnyi proezd 1, Chernogolovka, Moscow oblast, 142432, Russia

    A. V. Vinyukov, M. E. Dmitriev & V. V. Ragulin

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  1. A. V. Vinyukov
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  2. M. E. Dmitriev
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  3. V. V. Ragulin
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Corresponding author

Correspondence to V. V. Ragulin.

Additional information

Original Russian Text © A.V. Vinyukov, M.E. Dmitriev, V.V. Ragulin, 2015, published in Zhurnal Obshchei Khimii, 2015, Vol. 85, No. 2, pp. 192–195.

To the 80th Anniversary of B.I. Ionin

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Vinyukov, A.V., Dmitriev, M.E. & Ragulin, V.V. Amidoalkylation of phosphorous acid. Russ J Gen Chem 85, 366–369 (2015). https://doi.org/10.1134/S1070363215020036

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  • DOI: https://doi.org/10.1134/S1070363215020036

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