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Russian Journal of General Chemistry

, Volume 85, Issue 1, pp 280–288 | Cite as

Near-infrared photosensitizers based on nanostructured forms of phthalocyanine derivatives

  • I. G. MeerovichEmail author
  • E. V. Sanarova
  • G. A. Meerovich
  • V. M. Derkacheva
  • K. A. Volkov
  • V. M. Negrimovsky
  • S. V. Barkanova
  • E. A. Lukyanets
  • N. A. Oborotova
  • Z. S. Smirnova
  • L. M. Borisova
  • A. V. Lantsova
  • A. P. Polozkova
  • O. L. Orlova
  • V. B. Loschenov
  • L. V. Umnova
  • A. Yu. Baryshnikov
  • G. N. Vorozhtsov
Supplement: Rossiiskii Khimicheskii Zhurnal-Zhurnal Rossiiskogo Khimicheskogo Obshchestva im. D.I. Mendeleeva (Russian Chemistry Journal)

Abstract

The research is devoted to development and study of photosensitizers on a base of injectable nanoparticular formulations of phthalocyanine derivatives absorbing at long wavelength (near-infrared) range of 710–740 nm: Thiosens [liposomal form of aluminum hydroxide 1,8,15,22-tetrakis(phenylsulfanyl)phthalocyanine] and Octasens [polymeric micellar form of zinc 1,4,8,11,15,18,22,25-octachloro-2,3,9,10,16,17,23,24-octakis-(decylsulfanyl)phthalocyanine based on domestic poloxamer Emuxol-268]. Experiments have shown that the photosensitizers under study show high selectivity of accumulation and prolonged retaining at high concentration in tumor, relatively fast clearance from normal tissue and high therapeutic efficiency of photodynamic treatment on model tumors.

Keywords

General Chemistry Phthalocyanine Photodynamic Therapy Lewis Lung Carcinoma Liposomal Form 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Pleiades Publishing, Ltd. 2015

Authors and Affiliations

  • I. G. Meerovich
    • 1
    • 2
    Email author
  • E. V. Sanarova
    • 1
  • G. A. Meerovich
    • 3
  • V. M. Derkacheva
    • 4
  • K. A. Volkov
    • 4
  • V. M. Negrimovsky
    • 4
  • S. V. Barkanova
    • 4
  • E. A. Lukyanets
    • 4
  • N. A. Oborotova
    • 1
  • Z. S. Smirnova
    • 1
  • L. M. Borisova
    • 1
  • A. V. Lantsova
    • 1
  • A. P. Polozkova
    • 1
  • O. L. Orlova
    • 1
  • V. B. Loschenov
    • 3
  • L. V. Umnova
    • 4
  • A. Yu. Baryshnikov
    • 1
  • G. N. Vorozhtsov
    • 4
  1. 1.N.N. Blokhin Russian Cancer Research CenterMoscowRussia
  2. 2.Creighton UniversityOmahaUSA
  3. 3.Prokhorov Institute of General PhysicsRussian Academy of SciencesMoscowRussia
  4. 4.FSUE SSC “NIOPIK,”MoscowRussia

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