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Near-infrared photosensitizers based on nanostructured forms of phthalocyanine derivatives

  • Supplement: Rossiiskii Khimicheskii Zhurnal-Zhurnal Rossiiskogo Khimicheskogo Obshchestva im. D.I. Mendeleeva (Russian Chemistry Journal)
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Abstract

The research is devoted to development and study of photosensitizers on a base of injectable nanoparticular formulations of phthalocyanine derivatives absorbing at long wavelength (near-infrared) range of 710–740 nm: Thiosens [liposomal form of aluminum hydroxide 1,8,15,22-tetrakis(phenylsulfanyl)phthalocyanine] and Octasens [polymeric micellar form of zinc 1,4,8,11,15,18,22,25-octachloro-2,3,9,10,16,17,23,24-octakis-(decylsulfanyl)phthalocyanine based on domestic poloxamer Emuxol-268]. Experiments have shown that the photosensitizers under study show high selectivity of accumulation and prolonged retaining at high concentration in tumor, relatively fast clearance from normal tissue and high therapeutic efficiency of photodynamic treatment on model tumors.

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Authors and Affiliations

  1. N.N. Blokhin Russian Cancer Research Center, Kashirskoe sh. 24, Moscow, 115478, Russia

    I. G. Meerovich, E. V. Sanarova, N. A. Oborotova, Z. S. Smirnova, L. M. Borisova, A. V. Lantsova, A. P. Polozkova, O. L. Orlova & A. Yu. Baryshnikov

  2. Creighton University, 2500 California Plaza, Omaha, NE, 68178, USA

    I. G. Meerovich

  3. Prokhorov Institute of General Physics, Russian Academy of Sciences, Moscow, Russia

    G. A. Meerovich & V. B. Loschenov

  4. FSUE SSC “NIOPIK,”, Moscow, Russia

    V. M. Derkacheva, K. A. Volkov, V. M. Negrimovsky, S. V. Barkanova, E. A. Lukyanets, L. V. Umnova & G. N. Vorozhtsov

Authors
  1. I. G. Meerovich
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  2. E. V. Sanarova
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  3. G. A. Meerovich
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  4. V. M. Derkacheva
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  5. K. A. Volkov
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  6. V. M. Negrimovsky
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  7. S. V. Barkanova
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  8. E. A. Lukyanets
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  9. N. A. Oborotova
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  10. Z. S. Smirnova
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  11. L. M. Borisova
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  12. A. V. Lantsova
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  13. A. P. Polozkova
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  14. O. L. Orlova
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  15. V. B. Loschenov
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  16. L. V. Umnova
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  17. A. Yu. Baryshnikov
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  18. G. N. Vorozhtsov
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Corresponding author

Correspondence to I. G. Meerovich.

Additional information

Original Russian Text © I.G. Meerovich, E.V. Sanarova, G.A. Meerovich, V.M. Derkacheva, K.A. Volkov, V.M. Negrimovsky, S.V. Barkanova, E.A. Lukyanets, N.A. Oborotova, Z.S. Smirnova, L.M. Borisova, A.V. Lantsova, A.P. Polozkova, O.L. Orlova, V.B. Loschenov, L.V. Umnova, A.Yu. Baryshnikov, G.N. Vorozhtsov, 2013, published in Rossiiskii Khimicheskii Zhurnal, 2013, Vol. 57, No. 2, pp. 60–68.

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Meerovich, I.G., Sanarova, E.V., Meerovich, G.A. et al. Near-infrared photosensitizers based on nanostructured forms of phthalocyanine derivatives. Russ J Gen Chem 85, 280–288 (2015). https://doi.org/10.1134/S1070363215010430

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  • DOI: https://doi.org/10.1134/S1070363215010430

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