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Microwave-assisted synthesis of 8-aryl-10-chloro-4-methyl-2-oxo-2,8-dihydropyrano[2,3-f]chromene-9-carbaldehydes and their antimicrobial activity

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Abstract

A series of new coumarin-chromene hybrids have been synthesized by conventional and microwave irradiation methods from 8-aryl-4-methyl-8,9-dihydropyrano[2,3-f]chromene-2,10-diones using the Vilsmeier-Haack reagent. All the synthesized compounds were characterized by IR, 1H NMR, 13C NMR, MS, and elemental analyses and were screened for antibacterial and antifungal activity. Among the compounds tested, methoxy-substituted pyranochromenones revealed the best antimicrobial profile.

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Authors and Affiliations

  1. Department of Chemistry, Osmania University, Hyderabad, India

    D. Ashok, B. Vijaya Lakshmi, Arram Ganesh & S. Ravi

  2. Department of Biochemistry, Sri Venkateswara University, Tirupati, India

    S. Adam & S. D. S. Murthy

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  1. D. Ashok
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  2. B. Vijaya Lakshmi
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  3. Arram Ganesh
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  4. S. Ravi
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  5. S. Adam
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  6. S. D. S. Murthy
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Correspondence to D. Ashok.

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The text was submitted by the authors in English.

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Ashok, D., Vijaya Lakshmi, B., Ganesh, A. et al. Microwave-assisted synthesis of 8-aryl-10-chloro-4-methyl-2-oxo-2,8-dihydropyrano[2,3-f]chromene-9-carbaldehydes and their antimicrobial activity. Russ J Gen Chem 84, 2234–2239 (2014). https://doi.org/10.1134/S1070363214110322

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  • DOI: https://doi.org/10.1134/S1070363214110322

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