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Synthesis of aryl substituted quinones as β-secretase inhibitors: Ligand-free direct arylation of quinones with aryl halides

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Abstract

The simple ligand-free direct arylation of quinones with aryl halides applying Pd(OAc)2 as a catalyst in accordance with Heck reaction was studied. This reaction provided a simple and efficient synthetic approach to efficient inhibitors of β-secretase aryl-substituted quinones.

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Authors and Affiliations

  1. The Key Laboratory of Food Colloids and Biotechnology, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi, 214122, Jiangsu Province, China

    Dawei Wang, Bingyang Ge, Shuyan Yang, Hongyan Miao & Yuqiang Ding

Authors
  1. Dawei Wang
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  2. Bingyang Ge
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  3. Shuyan Yang
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  4. Hongyan Miao
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  5. Yuqiang Ding
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Correspondence to Dawei Wang.

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The text was submitted by the authors in English.

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Wang, D., Ge, B., Yang, S. et al. Synthesis of aryl substituted quinones as β-secretase inhibitors: Ligand-free direct arylation of quinones with aryl halides. Russ J Gen Chem 84, 1615–1621 (2014). https://doi.org/10.1134/S1070363214080295

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  • DOI: https://doi.org/10.1134/S1070363214080295

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