Abstract
A new method of the synthesis of heterocyclic derivatives of trifluoroalanine based on the cyclocondensation of methyl trifluoropyruvate tert-butoxycarbonylimine with C,N- and N,N-binucleophiles, like Nsubstituted ureas, 1-benzyl-6-aminouracil, benzamidine, and 3-aminocrotononitrile, followed by hydrolysis of the resulting Boc-derivatives to 5-amino-5-trifluoromethylimidazolidine-2,4-diones, 5-amino-5-trifluoromethyl-1-benzyl-5,7-dihydropyrrolo[2,3-d]-pyrimidine-2,4,6-3H-trione, 4-amino-2-methyl-5-oxo-4-(trifluoromethyl)-4,5-dihydro-1H-pyrrole-3-carbonitrile, or 5-amino-5-trifluoromethyl-2-phenyl-3,5-dihydroimidazol-4-one, respectively, was developed.
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Original Russian Text © V.B. Sokolov, A.Yu. Aksinenko, T.A. Epishina, T.V. Goreva, 2014, published in Zhurnal Obshchei Khimii, 2014, Vol. 84, No. 7, pp. 1163–1166.
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Sokolov, V.B., Aksinenko, A.Y., Epishina, T.A. et al. New heterocyclic derivatives of trifluoroalanine. Russ J Gen Chem 84, 1358–1361 (2014). https://doi.org/10.1134/S1070363214070184
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DOI: https://doi.org/10.1134/S1070363214070184