Skip to main content
SpringerLink
Log in

Application of charge-transfer complexation for evaluation of the drug-receptor mechanism of interaction: Spectroscopic and structure morphological properties of procaine and pilocarpine complexes with chloranilic acid acceptor

  • Published:
Russian Journal of General Chemistry Aims and scope Submit manuscript

Abstract

Study of the charge-transfer or proton-transfer interaction of drugs is important for understanding the drug-receptor interactions and the mechanism of drug action. In the current research the corresponding data were accumulated in the course of synthesis and study of the H-bonded complexes originated from the interaction between procaine (Pro) or pilocarpine (Pil) drugs and chloranilic acid (CLA). The targeted microstructure products have been isolated and characterized by elemental and spectral (electronic and vibrational) data. Microstructural properties of the reported complexes were studied with XRD and SEM techniques. The Pil drug containing complex exhibited a specific electronic spectrum with a strong, broad absorption band with much longer wavelength, λmax, than those typical for the individual reagents. It is noteworthy that the complex had good crystallinity. Application of Debye-Scherrer equation indicated that the reported complexes were in the range of nanosize.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Saravanabhavan, M., Sathya, K., Puranik, V.G., and Sekar, M., Spectrochim. Acta A 2014, no. 118, pp. 399–406.

    Google Scholar 

  2. Khan, I.M., Ahmad, A., and Ullah, M.F., J. Photochem. Photobio. B, 2011, no. 103, pp. 42–49.

    Google Scholar 

  3. Khan, I.M., Ahmad, A., and Ullah, M.F., Spectrochim. Acta A, 2013, no. 102, pp. 82–87.

    Google Scholar 

  4. Khan, I.M., Ahmad, A., and Aatif, M., J. Photochem. Photobio. B, 2011, no. 105, pp. 6–13.

    Google Scholar 

  5. Khan, I.M. and Ahmad, A., J. Mol. Struct., 2010, no. 975, pp. 381–388.

    Google Scholar 

  6. Khan, I.M. and Ahmad, A., J. Mol. Struct., 2010, no. 977, pp. 189–196.

    Google Scholar 

  7. Khan, I.M., Ahmad, A., and Kumar, S., J. Mol. Struct., 2013, no. 1035, pp. 38–45.

    Google Scholar 

  8. Eldaroti, H.H., Gadir, S.A., Refat, S.A., and Adam, A.M.A., Spectrochim. Acta A, 2013, no. 115, pp. 309–323.

    Google Scholar 

  9. Eldaroti, H.H., Gadir, S.A., Refat, S.A., and Adam, A.M.A., Spectrochim. Acta A, 2013, no. 109, pp. 259–271.

    Google Scholar 

  10. Eldaroti, H.H., Gadir, S.A., Refat, S.A., and Adam, A.M.A., J. Pharm. Anal., 2013, in press.

    Google Scholar 

  11. Eldaroti, H.H., Gadir, S.A., Refat, S.A., and Adam, A.M.A., Int. J. Electrochem. Sci., 2013, no. 8, pp. 5774–5800.

    Google Scholar 

  12. Yuan, J., Yin, J., Wang, E., J. Chromatogr. A, 2007, no. 1154, pp. 368–372.

    Google Scholar 

  13. Chen, Y., Lu, K., Hsiao, R., Lee, Y., Tsai, H., Lin, C.H., and Tsai, M., J. Comp. Biochem. Physiol. C, 2008, no. 148, pp. 128–135.

    Google Scholar 

  14. Karadaş, Ö, Omaç, Ö.K., Tok, F., Özgül, A., and Odabaşı, Z., J. Neurological Sci., 2012, no. 316, pp. 76–78.

    Google Scholar 

  15. Johnson, J.T., Ferretti, G.A., Nethery, W.J., Valdez, I.H., Fox, P.C., Ng, D., Muscoplat, C.C., and Gallagher, S.C., N. Engl. J. of Med., 1993, no. 5, pp. 390–395.

    Google Scholar 

  16. Vivino, F.B., Al-Hashimi, I., Khan, Z., LeVeque, F.G., Salisbury, P.L., Tran-Johnson, T.K., Muscoplat, C.C., Trivedi, M., Goldlust, B., and Gallagher, S.C., Arch. Intern. Med., 1999, no. 159, pp. 174–181.

    Google Scholar 

  17. Adam, A.M.A., J. Mol. Struct., 2012, no. 1030, pp. 26–39.

    Google Scholar 

  18. Adam, A.M.A., Refat, M.S., Saad, H.A., and Eldaroti, H.H., Eur. Chem. Bull., 2012, vol. 1(7), pp. 241–249.

    CAS  Google Scholar 

  19. Adam, A.M.A., Salman, M., Sharshar, T., and Refat, M.S., Int. J. Electrochem. Sci., 2013, no. 8, pp. 1274–1294.

    Google Scholar 

  20. Skoog, D.A., Principle of Instrumental Analysis, 3 ed., Saunders College Publishing, New York, USA, 1985.

    Google Scholar 

  21. Briegleb, G., Z. Angew. Chem., 1964, no. 3, pp. 617–632.

    Google Scholar 

  22. Tsubomura, H. and Lang, R.P., J. Am. Chem. Soc., 1961, no. 83, pp. 2085–2092.

    Google Scholar 

  23. Rathone, R., Lindeman, S.V., and Kochi, J.K., J. Am. Chem. Soc., 1997, no. 119, pp. 9393–9404.

    Google Scholar 

  24. Martin, A.N., Swarbrick, J., and Cammarata, V, Physical Pharmacy, 3 ed., Lee and Febiger, Philadelphia, PA, 1969, p. 344.

    Google Scholar 

  25. Adam, A.M.A., Refat, M.S., and Saad, H.A., J. Mol. Struct., 2013, no. 1051, pp. 144–163.

    Google Scholar 

  26. Adam, A.M.A., Refat, M.S., and Saad, H.A., J. Mol. Struct., 2013, no. 1037, pp. 376–392.

    Google Scholar 

  27. Adam, A.M.A., Spectrochim. Acta A, 2013, no. 104, pp. 1–13.

    Google Scholar 

  28. Khan, I.M. and Ahmad, A., J. Mol. Struct., 2013, no. 1050, pp. 122–127.

    Google Scholar 

  29. Klug, H.P. and Alexander, L.E., X-Ray Diffraction Procedures for Polycrystalline and Amorphous Materials, New York: Wiley, 1974.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, Taif University, Al-Haweiah, P.O. Box 888, Zip Code 21974, Taif, Saudi Arabia

    Abdel Majid A. Adam

Authors
  1. Abdel Majid A. Adam
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Abdel Majid A. Adam.

Additional information

The text was submitted by the author in English.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Adam, A.M.A. Application of charge-transfer complexation for evaluation of the drug-receptor mechanism of interaction: Spectroscopic and structure morphological properties of procaine and pilocarpine complexes with chloranilic acid acceptor. Russ J Gen Chem 84, 1225–1236 (2014). https://doi.org/10.1134/S1070363214060292

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S1070363214060292

Keywords

Search

Navigation