Abstract
The correlation models describing the quantitative structure-activity relationship have been developed for a series of the apoptosis-inducing 4-aryl-4H-chromenes and 4-aryl-2H-chromenes taking advantage of the fragment descriptors of the molecular structure. The set of models have been picked up, containing no more than 28 parameters and having the standard deviation of the predicted apoptosis-inducing activity of below 0.3 logarithmic units. Basing of the frequency of the descriptors in the 438 picked models, the structural elements crucial for the pro-apoptosis activity have been detected. The structural modifications have been suggested to enhance the studied activity of the compounds.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Programmed Cell Death in Cancer Progression and Therapy, Khosravi-Far, R. and White, E., Eds., Springer Netherlands, 2008. 356 p.
Fuller, G., and Shilds, D., Molekulyarnaya biologiya kletki, Moscow: Binom-Press, 2006, p.152. Translated under the title Fuller, G., Molecular Basis of Medical Cell Biology, McGraw-Hill Publishing Co., 1998.
Stanton, R.A., Gernert, K.M., Nettles, J.H., and Aneja, R., Med. Res. Rev., 2011, vol. 31, no. 3, p. 443.
Kemnitzer, W., Drewe, J., Jiang, S., Zhang, H., Zhao, J., Crogan-Grundy, C., Xu, L., Lamothe, S., Gourdeau, H., Denis, R., Tseng, B., Kasibhatla, S., and Cai, S.X., J. Med. Chem., 2007, vol. 50, no. 12, p. 2858.
Kemnitzer, W., Drewe, J., Jiang, S., Zhang, H., Zhao, J., Jia, S., Herich, J., Labrecque, D., Storer, R., Meerovitch, K., Bouffard, D., Rej, R., Denis, R., Blais, Ch., Lamothe, S., Attardo, G., Gourdeau, H., Tseng, B., Kasibhatla, S., and Cai, S.X., J. Med. Chem., 2004, vol. 47, no. 25, p. 6299.
Kemnitzer, W., Kasibhatla, S., Jiang, S., Zhang, H., Zhao, J., Jia, Sh., Xu, L., Crogan-Grundy, C., Denis, R., Barriault N., Vaillancourt, L., Charron, S., Dodd, J., Attardo, G., Labrecque, D., Lamothe, S., Gourdeau, H., Tseng, B., Drewe, J., and Cai, S.X., Bioorg. Med. Chem. Lett., 2005, vol. 15, no. 21, p. 4745.
Kemnitzer, W., Drewe, J., Jiang, S., Zhang, H., Crogan-Grundy, C., Labrecque, D., Bubenick, M., Attardo, G., Denis, R., Lamothe, S., Gourdeau, H., Tseng, B., Kasibhatla, S., and Cai, S.X., J. Med. Chem., 2008, vol. 51, no. 3, p. 417.
Kemnitzer, W., Jiang, S., Wang, Y., Kasibhatla, S., Crogan-Grundy, C., Bubenick, M., Labrecque, D., Denis, R., Lamothe, S., Attardo, G., Gourdeau, H., Tseng, B., and Drewe, J., Cai, S.X., Bioorg. Med. Chem. Lett., 2008, vol. 18, no. 2, p. 603.
Kemnitzer, W., Jiang, S., Zhang, H., Kasibhatla, S., Crogan-Grundy, C., Blais, Ch., Attardo, G., Denis, R., Lamothe, S., Gourdeau, H., Tseng, B., Drewe, J., and Cai, S.X., Bioorg. Med. Chem. Lett., 2008, vol. 18, no. 20, p. 5571.
Cai, S.X., Nguyen, B., Jia, S., Herich, J., Guastelle, J., Reddy, S., Tseng, B., Drewe, J., and Kasibhatla, S., J. Med. Chem., 2003, vol. 46, no. 12, p. 2474.
Golovanov, I.B. and Zhenodarova, S.M., Russ. J. Gen. Chem., 2003, vol. 73, no. 1, p. 85.
Golovanov, I.B. and Tsygankova, I.G., Zh. Obshch. Khim., 1999, vol. 69, no. 8, p. 1275.
Golovanov, I.B. and Tsygankova, I.G., Quantitative Structure — Activity Relationships (QSAR), 2000, vol. 19, p. 554.
Tsygankova, I.G. and Zhenodarova, S.M., Russ. J. Gen. Chem., 2008, vol. 78, no. 9, p. 1760.
Author information
Authors and Affiliations
Corresponding author
Additional information
Original Russian Text © I.G. Tsygankova, S.M. Zhenodarova, 2014, published in Zhurnal Obshchei Khimii, 2014, Vol. 84, No. 1, pp. 93–101.
Rights and permissions
About this article
Cite this article
Tsygankova, I.G., Zhenodarova, S.M. Activity of 4-arylchromene derivatives as apoptosis inductors and potential anticancer drugs. Russ J Gen Chem 84, 89–97 (2014). https://doi.org/10.1134/S1070363214010149
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S1070363214010149