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Cyclocondensation of methyl 2-(5-methylisoxazol-3-yl)imino-3,3,3-trifluoropropionate with 1,3-binucleophiles

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Abstract

Cyclocondensation of methyl 2-(5-methylisoxazol-3-yl)imino-3,3,3-trifluoropropionate with 1,3-binucleophiles such as benzamidines, aminothiazoline, and 2-aminocrotonic acid nitrile results in trifluoromethyl-containing 3,5-dihydro-4-ones, 2,3-dihydro-6H-imidazo[2,1-b]thiazol-5-one, and 4,5-dihydro-1H-pyrrole-3-carbonitrile.

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References

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Authors and Affiliations

  1. Institute of Physiologically Active Compounds, Russian Academy of Sciences, 1 Severnyi pr., Chernogolovka, Moscow oblast, 142432, Russia

    V. B. Sokolov, A. Yu. Aksinenko & I. V. Martynov

Authors
  1. V. B. Sokolov
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  2. A. Yu. Aksinenko
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  3. I. V. Martynov
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Correspondence to A. Yu. Aksinenko.

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Original Russian Text © V.B. Sokolov, A.Yu. Aksinenko, I.V. Martynov, 2014, published in Zhurnal Obshchei Khimii, 2014, Vol. 84, No. 1, pp. 90–92.

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Sokolov, V.B., Aksinenko, A.Y. & Martynov, I.V. Cyclocondensation of methyl 2-(5-methylisoxazol-3-yl)imino-3,3,3-trifluoropropionate with 1,3-binucleophiles. Russ J Gen Chem 84, 86–88 (2014). https://doi.org/10.1134/S1070363214010137

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  • DOI: https://doi.org/10.1134/S1070363214010137

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