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Low-toxicity complexes with nitrogen-containing ligands as promising new agents for treatment and prevention of free radical states

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Abstract

A method for synthesis of complexes with 1,5-pentamethylenetetrazole ligand was proposed. These compounds hold promise for antioxidant treatment of so-called “free radical” diseases of different geneses, including those caused by unfavorable environmental factors. The antioxidant activity of the complexes synthesized was tested by two independent methods: by assessing the ability to inhibit lipid peroxidation and by measuring the SOD-like activity.

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Authors and Affiliations

  1. St. Petersburg State Institute of Technology (Technical University), Moskovskii pr. 26, St. Petersburg, 190013, Russia

    I. V. Shugalei, M. A. Ilyushin, V. V. Sokolova, N. P. Dubyago, I. V. Bachurina & A. V. Garabadzhiu

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  1. I. V. Shugalei
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  2. M. A. Ilyushin
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  3. V. V. Sokolova
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  4. N. P. Dubyago
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  5. I. V. Bachurina
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  6. A. V. Garabadzhiu
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Correspondence to I. V. Shugalei.

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Original Russian Text © I.V. Shugalei, M.A. Ilyushin, V.V. Sokolova, N.P. Dubyago, I.V. Bachurina, A.V. Garabadzhiu, 2013, published in Ekologicheskaya Khimiya, 2013, Vol. 22, No. 1, pp. 32–40.

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Shugalei, I.V., Ilyushin, M.A., Sokolova, V.V. et al. Low-toxicity complexes with nitrogen-containing ligands as promising new agents for treatment and prevention of free radical states. Russ J Gen Chem 83, 2701–2708 (2013). https://doi.org/10.1134/S1070363213130161

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