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Cyanoselenoacetamide in a new synthesis of propane-bis(thioamide), the promising reagent for heterocyclizations

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Abstract

Cyanoselenoacetamide reacts with hydrogen sulfide to form propane-bis(thioamide), which can be used to produce thiazoles (the Hantzsch synthesis) and 3-thioxo-1-phenyl-2,3,5,6,7,8-hexahydroisoquinoline-4-carbonitrile. From the latter compound, 2-alkylsulfanyl-1-phenyl-5,6,7,8-tetrahydroisoquinoline-4-carbonitriles and 1-amino-N-(4-bromophenyl)-5-phenyl-6,7,8,9-tetrahydrothieno[2,3-c]isoquinoline-2-carboxamide can be prepared.

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Authors and Affiliations

  1. Taras Shevchenko Luhansk National University, ul. Oboronnaya 2, Luhansk, 91011, Ukraine

    I. V. Dyachenko

  2. Institute of Organic Chemistry, National Academy of Sciences of Ukraine, ul. Murmanskaya 5, Kiev, 02660, Ukraine

    M. V. Vovk

Authors
  1. I. V. Dyachenko
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  2. M. V. Vovk
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Correspondence to I. V. Dyachenko.

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Original Russian Text © I.V. Dyachenko, M.V. Vovk, 2013, published in Zhurnal Obshchei Khimii, 2013, Vol. 83, No. 9, pp. 1504–1508.

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Dyachenko, I.V., Vovk, M.V. Cyanoselenoacetamide in a new synthesis of propane-bis(thioamide), the promising reagent for heterocyclizations. Russ J Gen Chem 83, 1724–1728 (2013). https://doi.org/10.1134/S1070363213090168

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  • DOI: https://doi.org/10.1134/S1070363213090168

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