Abstract
Kinetics and mechanism of transaldimination of amino acids and aromatic amines with pyridoxal have been studied by means of UV spectroscopy and polarimetry. It has been shown that aminal intermediates are formed in reaction of the Schiff’s bases with p-aminobenzoic acid and β-alanine. The structure of aminal and Schiff’s base is determined by the spatial arrangement of the amino acid and aromatic fragments with respect to the pyridine ring plane. The presence of OH and CH2-OH groups in the o-positions in pyridoxal structure turns amino groups by 90° with respect to the pyridine ring. The scheme of Schiff’s bases transaldimination by amino acids and biological amines has been developed according to stereospecific, energy, and geometric factors.
Similar content being viewed by others
References
Pishchugin, F.V. and Tuleberdiev, I.T., Russ. J. Gen. Chem., 2005, vol. 75, no. 9, pp. 1465–1468.
Pishchugin, F.V. and Tuleberdiev, I.T., Russ. J. Gen. Chem., 2008, vol. 78, no. 6, pp. 1225–1229.
Pishchugin, F.V. and Tuleberdiev, I.T., Russ. J. Gen. Chem., 2009, vol. 79, no. 1, pp. 117–120.
Pishchugin, F.V. and Tuleberdiev, I.T., Russ. J. Gen. Chem., 2010, vol. 80, no. 9, pp. 1836–1840.
Metzler, D.E., Biochemistry: The Chemical Reactions of Living Cells, New York: Academic Press, 1977.
Braunshtein, A.E. and Shemiakin, M.M., Biokhim., 1953, vol. 18, no. 4, pp. 393–411.
Author information
Authors and Affiliations
Corresponding author
Additional information
Original Russian Text © F.V. Pishchugin, I.T. Tuleberdiev, 2013, published in Zhurnal Obshchei Khimii, 2013, Vol. 83, No. 6, pp. 946–949.
Rights and permissions
About this article
Cite this article
Pishchugin, F.V., Tuleberdiev, I.T. Kinetics and mechanism of transaldimination of amino acids and aromatic amines with pyridoxal. Russ J Gen Chem 83, 1077–1080 (2013). https://doi.org/10.1134/S1070363213060121
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S1070363213060121