Abstract
4-Arylaminomethylene-3-methyl-1-(6-methyl-4-oxo-1,4-dihydropyrimidin-2-yl)pyrazol-5(4H)-ones were synthesized by a three-component reaction between the 6-methyl-2-(3-methyl-5-oxo-2,5-dihydropyrazol-1-yl)pyrimidin-4(1H)-one, triethoxymethane, and an aromatic amine. These compounds were found to exist as aminomethyleneketones regardless of the electronic effects of substituents in the aromatic fragments. The resulting compounds showed pronounced tuberculocidic activity.
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Erkin, A.V. and Krutikov, V.I., Abstract of Papers, 10th Int. Scientific-Research Conf. “Science-Capacious Chemical Technologies,” Volgograd, 2004, vol. 1, p. 245.
Erkin, A.V. and Krutikov, V.I., Zh. Obshch. Khim., 2008, vol. 78, no. 2, p. 324.
Erkin, A.V., Krutikov, V.I., and Chubraev, M.A., Zh. Obshch. Khim., 2004, vol. 74, no. 3, p. 466.
Cristea, I., Studia Universitatis Babes-Bolyai, Seria Chemia, 1988, vol. 33, no. 2, p. 61.
Erkin, A.V. and Krutikov, V.I., Zh. Obshch. Khim., 2009, vol. 79, no. 7, p. 1168.
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Original Russian Text © A.V. Erkin, V.I. Krutikov, A.A. Ivanov, 2012, published in Zhurnal Obshchei Khimii, 2012, Vol. 82, No. 1, pp. 156–159.
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Erkin, A.V., Krutikov, V.I. & Ivanov, A.A. Synthesis and tuberculocidic activity of some 4-arylaminomethylene-3-methyl-1-(pyrimidin-2-yl)pyrazol-5(4H)-ones. Russ J Gen Chem 82, 153–156 (2012). https://doi.org/10.1134/S1070363212010252
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DOI: https://doi.org/10.1134/S1070363212010252