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Reaction of acetyl- and 1,1′-diacetylferrocene with isatin (Pfitzinger reaction)

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Abstract

An efficient method for the synthesis of 2-ferrocenyl-substituted quinoline-4-carboxylic acids via the reaction of acetyl- and 1,1′-diacetylferrocene with isatin under the conditions of the Pfitzinger reaction was developed. Starting from the obtained acids methyl esters, amides, N-methyl-N-methoxyamides, and oximes (at one of the free acetyl groups) of some of these compounds were synthesized.

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Authors and Affiliations

  1. Lipetsk State Pedagogical University, ul. Lenina 42, Lipetsk, 398020, Russia

    A. I. Moskalenko, A. V. Boeva & V. I. Boev

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  1. A. I. Moskalenko
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  2. A. V. Boeva
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  3. V. I. Boev
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Correspondence to A. I. Moskalenko.

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Original Russian Text © A.I. Moskalenko, A.V. Boeva, V.I. Boev, 2011, published in Zhurnal Obshchei Khimii, 2011, Vol. 81, No. 3, pp. 439–445.

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Moskalenko, A.I., Boeva, A.V. & Boev, V.I. Reaction of acetyl- and 1,1′-diacetylferrocene with isatin (Pfitzinger reaction). Russ J Gen Chem 81, 535–541 (2011). https://doi.org/10.1134/S1070363211030157

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  • DOI: https://doi.org/10.1134/S1070363211030157

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