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Sulfanilamide copper(II) chelates with 2-[(2-hydroxyphenyl-imino)methyl]phenolom and 1-[(2-hydroxyphenylimino)-methyl]naphthalen-2-ol

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Abstract

2-[(2-Hydroxyphenylimino)methyl]phenol (H2L1) and 1-[(2-hydroxyphenylimino)methyl]naphthalen-2-ol (H2L2) reacted with copper(II) acetate hydrate and sulfanilamide (Sf1), sulfathiazole (Sf2), sulfaethidole (Sf3), sulfadiazine (Sf4), and sulfadimidine (Sf5) in ethanol to give mixed-ligand copper chelates with the composition Cu(Sf1–5)(L1–2) · n H2O (n = 1, 2). All these complexes are monomeric. Salicylaldehyde imines (H2L1 and H2L2) behave as doubly deprotonated tridentate O,N,O ligands, whereas sulfanilamides (Sf1–5) are unidentate ligands. Thermolysis of the synthesized complexes includes dehydration at 70–90°C, followed by complete thermal decomposition (290–380°C). The complexes [Cu(Sf1)(L1)] · 2H2O and [Cu(Sf3)(L1)] · H2O at a concentration of 10−4 M inhibited growth and reproduction of 100% of human myeloid leukemia cells (HL-60). The inhibitory effect was 90 and 75%, respectively, at a concentration of 10−5 M, whereas no antitumor activity was observed at a concentration of 10−6 M.

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Authors and Affiliations

  1. Moldavian State University, ul. Mateevicha 60, Kishinev, 2009, Moldova

    A. P. Gulya & V. I. Tsapkov

  2. Université Laval, 2325, rue de l’Université, Québec, G1V 4G2, Canada

    D. Poirier

  3. Alexandru Ioan Cuza University of Iaşi, Bulevardul Carol I, Nr. 11, Iasi, 700506, Romania

    K. Aruksandei

  4. Universitatea de Medicina si Farmacie “Carol Davila,”, Strada Dionisie Lupu 37, Bucuresti, Romania

    E. Pakhontsu

Authors
  1. A. P. Gulya
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  2. V. I. Tsapkov
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  3. D. Poirier
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  4. K. Aruksandei
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  5. E. Pakhontsu
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Correspondence to A. P. Gulya.

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Original Russian Text © A.P. Gulya, V.I. Tsapkov, D. Poirier, K. Aruksandei, E. Pakhontsu, 2010, published in Zhurnal Obshchei Khimii, 2010, Vol. 80, No. 7, pp. 1185–1188.

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Gulya, A.P., Tsapkov, V.I., Poirier, D. et al. Sulfanilamide copper(II) chelates with 2-[(2-hydroxyphenyl-imino)methyl]phenolom and 1-[(2-hydroxyphenylimino)-methyl]naphthalen-2-ol. Russ J Gen Chem 80, 1351–1354 (2010). https://doi.org/10.1134/S1070363210070224

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  • DOI: https://doi.org/10.1134/S1070363210070224

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