Russian Journal of General Chemistry

, Volume 80, Issue 4, pp 836–841 | Cite as

A Study of alkylation regioselectivity of 5-substituted tetrazoles with chloroacetamides

  • N. T. Pokhodylo
  • R. D. Savka
  • V. S. Matiichuk
  • N. D. ObushakEmail author


Alkylation of 5-aryltetrazoles with N-arylchloroacetamides commonly proceeds regioselectively at 2 position of the tetrazole ring. The ratio of 1,5- and 2,5-regioisomers depends on the nature of a substituents in the benzene ring of the N-arylchloroacetamide and position of a substituent in the aryltetrazole aryl group. Features of 1H NMR spectra of the synthesized compounds are discussed.


Alkylation General Chemistry Tetrazole Ring Chloroacetamide Chloroacetanilide 
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Copyright information

© Pleiades Publishing, Ltd. 2010

Authors and Affiliations

  • N. T. Pokhodylo
    • 1
  • R. D. Savka
    • 1
  • V. S. Matiichuk
    • 1
  • N. D. Obushak
    • 1
    Email author
  1. 1.Ivan Franko Lviv National UniversityLvivUkraine

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