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Transformation of substituted 5-amino-1,3-oxazole-4-carbonitriles into new 3,4,5-triaminopyrazole derivatives

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Abstract

Reactions of accessible 5-alkylamino- and 5-arylamino-1,3-oxazole-4-carbonitriles with hydrazine hydrate on heating involved a complex transformation sequence resulting in the formation of 3,4,5-triaminopyrazole derivatives. The structure of the products was confirmed by their cyclocondensation with acetylacetone, leading to 2-alkyl(aryl)amino-3-acylamino-5,7-dimethylpyrazolo[1,5-a]pyrimidines which were identified by NMR spectroscopy using COSY, NOESY, HMQC, and HMBC techniques.

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Authors and Affiliations

  1. Institute of Bioorganic and Petroleum Chemistry, National Academy of Sciences of Ukraine, ul. Murmanskaya 1, Kiev, 02660, Ukraine

    A. P. Kozachenko, O. V. Shablykin, A. N. Vasilenko & V. S. Brovarets

Authors
  1. A. P. Kozachenko
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  2. O. V. Shablykin
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  3. A. N. Vasilenko
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  4. V. S. Brovarets
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Corresponding author

Correspondence to V. S. Brovarets.

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Original Russian Text © A.P. Kozachenko, O.V. Shablykin, A.N. Vasilenko, V.S. Brovarets, 2010, published in Zhurnal Obshchei Khimii, 2010, Vol. 80, No. 1, pp. 133–138.

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Kozachenko, A.P., Shablykin, O.V., Vasilenko, A.N. et al. Transformation of substituted 5-amino-1,3-oxazole-4-carbonitriles into new 3,4,5-triaminopyrazole derivatives. Russ J Gen Chem 80, 127–132 (2010). https://doi.org/10.1134/S1070363210010172

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  • DOI: https://doi.org/10.1134/S1070363210010172

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