Skip to main content
SpringerLink
Log in

5-Arylideneaminouracils: I. Synthesis and relations between physicochemical parameters and biological activity

  • Published:
Russian Journal of General Chemistry Aims and scope Submit manuscript

Abstract

A number of 5-arylideneaminouracils were synthesized by condensation of 5-aminouracil with substituted aromatic aldehydes. Correlation analysis according to Hantzsch revealed strong effects of the lipophilicity parameter and hydration energy of these compounds on their biological activity.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Chakraborti, S.K. and Barun Kumar, J. Indian Chem. Soc., 1973, vol. 50, no. 1, p. 137.

    CAS  Google Scholar 

  2. Cherayath, S., Chathakudam, A., and Prabhakaran, P., Transition Met. Chem., 1990, vol. 15, no. 6, p. 449.

    Article  CAS  Google Scholar 

  3. Enrique, C., Garcia, A., Salas, J.M., and Alvarez de Cientuegos, G., Transition Met. Chem., 1992, vol. 17, no. 5, p. 464.

    Article  CAS  Google Scholar 

  4. Seitembetov, T.S., Izv. Min. Nauki-Akad. Nauk Kazakhstana, Ser. Khim., 1996, no. 4, p. 87.

  5. Russian Patent no. 2 198 166, 2003; Ref. Zh., Khim., 2003, no. 19 O 111 P.

  6. Vereshchagin, A.N., Induktivnyi effekt. Konstanty zamestitelei dlya korrelyatsionnogo analiza (Inductive Effect. Substituent Constants for Correlation Analysis), Moscow: Nauka, 1988.

    Google Scholar 

  7. Krutikov, V.I. and Lavrent’ev, A.N., Zh. Obshch. Khim., 1990, vol. 60, no. 6, p. 1270.

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. St. Petersburg State Institute of Technology, Moskovskii pr. 26, St. Petersburg, 190013, Russia

    V. I. Krutikov & A. V. Erkin

Authors
  1. V. I. Krutikov
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. V. Erkin
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to V. I. Krutikov.

Additional information

Original Russian Text © V.I. Krutikov, A.V. Erkin, 2009, published in Zhurnal Obshchei Khimii, 2009, vol. 79, No. 5, pp. 813–818.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Krutikov, V.I., Erkin, A.V. 5-Arylideneaminouracils: I. Synthesis and relations between physicochemical parameters and biological activity. Russ J Gen Chem 79, 985–990 (2009). https://doi.org/10.1134/S107036320905020X

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S107036320905020X

Keywords

Search

Navigation