Abstract
The effect of glutathione on the active oxygen reduction products at copper and platinum electrodes was studied by chronovoltammetry and pulse voltammetry. Electrochemical reduction of glutathione at the same electrodes was also examined. A mechanism was proposed for the reaction of glutathione with oxygen and its active forms, and attempts were made to simulate redox reactions initiating oxidative stress in vitro and glutathione effect thereon by electrochemical methods.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Halliwell, B. and Gutteridge, J.M.C., Free Radicals in Biology and Medicine, Oxford: Clarendon, 1999, pp. 530, 617.
Handbook of Oxidants and Antioxidants in Exercise, Sen, C.K., Packer, L., and Hänninen, O.O.P., Eds., Amsterdam: Elsevier, 2000, p. 57.
Fontecave, M. and Pierre, J.L., Bull. Soc. Chim. Fr., 1991, vol. 128, p. 502.
Kulinskii, V.I. and Kolesnichenko, L.S., Usp. Sovr. Biol., 1993, vol. 113, no. 1, p. 107.
Dubinina, E.E., Vopr. Med. Khim., vol. 47, no. 6, p. 561.
Forman, H.J. and Torres, M., Mol. Aspects Med., 2001, vol. 22, p. 189.
Kohen, R. and Gati, I., Toxicology, 2000, vol. 148, p. 149.
Gul, M., Kutay, F.Z., Temocin, S., and Hanninen, O., Indian J. Exp. Biol., 2000, vol. 38, p. 625.
Lushchak, V.I., Biokhimiya, 2007, vol. 72, no. 8, p. 995.
Prutz, W.A., Butler, J., and Land, E.J., Biophys. Chem., 1994, vol. 49, p. 101.
Kornienko, I.V., Kletskii, M.E., and Olekhnovich, L.P., Biotekhnologiya, 2003, no. 2, p. 83.
Seymour, E.H., Wilkins, S.J., Lawrence, N.S., and Compton, R.G., Anal. Lett., 2002, vol. 35, no. 8, p. 1387.
Stepuro, I.I., Sokolovskaya, S.N., and Solodunov, A.A., Biofizika, 1995, no. 40, p. 1158.
Armstrong, F.A., Russ. J. Electrochem., 2002, vol. 38, no. 1, p. 49.
Jin, W., Zhao, X., and Xiao, L., Electoanalysis, 2000, vol. 12, p. 858.
Ossendorfova, N., Pradac, J., and Koryta, J., J. Electroanal. Chem., 1970, vol. 28, p. 311.
Fang, C. and Zhou, H., Electroanalysis, 2003, vol. 15, p. 1632.
Shapoval, G.S. and Gromovaya, V.F., Ukr. Biokhim. Zh., 2003, vol. 75, no. 2, p. 5.
Gromovaya, V.F., Shapoval, G.S., and Mironyuk, I.E., Russ. J. Gen. Chem., 2002, vol. 72, no. 5, p. 774.
Author information
Authors and Affiliations
Corresponding author
Additional information
Original Russian Text © G.S. Shapoval, V.F. Gromovaya, I.E. Mironyuk, O.S. Kruglyak, 2008, published in Zhurnal Obshchei Khimii, 2008, Vol. 78, No. 12, pp. 2040–2044.
Rights and permissions
About this article
Cite this article
Shapoval, G.S., Gromovaya, V.F., Mironyuk, I.E. et al. Electrochemical simulation of redox reactions of glutathione. Russ J Gen Chem 78, 2386–2390 (2008). https://doi.org/10.1134/S1070363208120153
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S1070363208120153