Skip to main content
SpringerLink
Log in

Synthesis of 2-(4-chlorobenzylamino)-1-(4-nitrophenyl)ethanol and its chemical transformations

  • Published:
Russian Journal of General Chemistry Aims and scope Submit manuscript

Abstract

By the ring cleavage of p-nitrophenyloxirane with p-chlorobenzylamine the corresponding chlorobenzyl- and nitrophenyl-substituted aminoethanol was obtained that was brought into reactions of glycosylation, reduction and substitution aimed at the preparation and designing of new structures containing pharmacalogically active functional groups. Among the synthesized compounds a compound is revealed possessing moderately expressed antibacterial and antifungal activity.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Belikov, V.G., Farmatsevticheskaya khimiya (Pharmaceutical Chemistry), Moscow: Vysshaya Shkola, 1985.

    Google Scholar 

  2. Shemyakin, M.M., Khokhlov, A.S., and Kolosov, M.N., Khimiya antibiotikov (Chemistry of Antibiotics), Moscow: Akad. Nauk SSSR, 1961, p. 337.

    Google Scholar 

  3. Mashkovskii, M.D., Lekarstvennye sredstva (Drugs), 15th edition, Moscow: Novaya volna, 2007, p. 814.

    Google Scholar 

  4. Malinovskii, M.S., Okisi olefinov i ikh proizvodnye (Olefin Oxides and Their Derivatives), Moscow: Goskhimizdat, 1961.

    Google Scholar 

  5. Kas’yan, L.I., Golodaeva, E.A., Kas’yan, A.O., and Isaev, A.K., Zh. Org. Khim., 2003, vol. 39, no. 10, p. 1472.

    Google Scholar 

  6. Sarymzakova, R.K. Abdurashitova, Yu.A., and Dzhamanbaev, Zh.A., Vestn. Mosk. Gos. Univ., Ser. 2, 2006, vol. 47, no. 3, p. 242.

    CAS  Google Scholar 

  7. Soldatenkov, A.T., Kolyadina, N.M., and Shendrik, I.V. Osnovy organicheskoi khimii lekarstvennykh veshchestv (Fundamentals of Organic Chemistry of Pharmaceuticals), Moscow: Khimiya, 2001.

    Google Scholar 

  8. Chemistry of Nitro and Nitroso Groups, Feuer, H. Ed., Moscow: Mir, 1973, vol. 2, p. 197.

    Google Scholar 

  9. Kulakov, I.V., Zhambekov, Z.M., Fazylov, S.D., and Muldakhmetov, Z.M., Izv. Nat. Akad. Sci. of Kazakhstan, Ser. Khim., 2007, no. 6, p. 52.

Download references

Author information

Authors and Affiliations

  1. Institute of Organic Synthesis and Coal Chemistry of Kazakhstan, ul. Alikhanova 1, Karaganda, 100008, Kazakhstan

    I. V. Kulakov, Z. M. Zhambekov, S. D. Fazylov & O. A. Nurkenov

Authors
  1. I. V. Kulakov
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Z. M. Zhambekov
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. S. D. Fazylov
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. O. A. Nurkenov
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to I. V. Kulakov.

Additional information

Original Russian Text © I.V. Kulakov, Z.M. Zhambekov, S.D. Fazylov, O.A. Nurkenov, 2008, published in Zhurnal Obshchei Khimii, 2008, Vol. 78, No. 12, pp. 2028–2032.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kulakov, I.V., Zhambekov, Z.M., Fazylov, S.D. et al. Synthesis of 2-(4-chlorobenzylamino)-1-(4-nitrophenyl)ethanol and its chemical transformations. Russ J Gen Chem 78, 2374–2378 (2008). https://doi.org/10.1134/S107036320812013X

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S107036320812013X

Keywords

Search

Navigation