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Alkylated chitosans of low molecular weight as non-viral transfection vectors for gene therapy

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Abstract

Low molecular weight chitosans (5 kDa) hydrophobically modified with 3, 10, and 18 mol % of tetradecenoyl (TDC) groups have been synthesized. Their good solubility at neutral pH, their surface activity and micelle-forming properties as well as their ability to interact with negatively charged phospholipid vesicles mimicking the internal layer of cell plasma membranes, allow us to consider them as potential non-viral transfection vectors for gene therapy.

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Authors and Affiliations

  1. Department of Pharmacology and Physicochemistry at Institut Gilbert Laustriat, Pharmaceutical Faculty, Lois Pasteur University, Lois Pasteur, France

    Xin Zhang, Y. Mély & G. Duportail

  2. Scientific Center TUBITAK Marmara, TUBITAK Marmara, Turkey

    S. Ercelen & V. G. Babak

  3. Nesmeyanov Institute of Organoelemental Compounds, Russian Academy of Sciences, uд. Vavilova 28, Moscow, 119991, Russia

    V. E. Tikhonov

  4. Laboratory of Experimental Physics at the Complex Research Institute, Russian Academy of Sciences, Groznyi, Russian Federation

    S. Z. Karaeva

  5. Research Institute of Grippe, Russian Academy of Medical Sciences, ul. Prof. Popova 15/17, Saint-Petersburg, 197376, Russia

    A. V. Slita & V. V. Zarubaev

Authors
  1. Xin Zhang
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  2. S. Ercelen
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  3. V. E. Tikhonov
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  4. S. Z. Karaeva
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  5. A. V. Slita
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  6. V. V. Zarubaev
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  7. Y. Mély
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  8. G. Duportail
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  9. V. G. Babak
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Corresponding author

Correspondence to V. G. Babak.

Additional information

Original Russian Text © Xin Zhang, S. Ercelen, V.E. Tikhonov, S.Z. Karaeva, A.V. Slita, V.V. Zarubaev, Y. Mély, G. Duportail, V.G. Babak, 2008, published in Rossiiskii Khimicheskii Zhurnal, 2007, Vol. 51, No. 6, pp. 81–88.

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Zhang, X., Ercelen, S., Tikhonov, V.E. et al. Alkylated chitosans of low molecular weight as non-viral transfection vectors for gene therapy. Russ J Gen Chem 78, 1093–1102 (2008). https://doi.org/10.1134/S1070363208050423

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  • DOI: https://doi.org/10.1134/S1070363208050423

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