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Preparation and biological properties of inclusion compounds of calix[4]arene and 1,4-benzodiazepinone derivatives

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Abstract

The possibility of enhancing the oral bioavailability of certain 1,4-benzodiazepinones by using them as complexes with a series of calix[4]arene derivatives was examined. All the inclusion compounds prepared exhibit anticonvulsant activity by antagonism with Corazol spasmodic agent. Complexes with 25,27-bis[(hydrazinocarbonyl)methoxy]-26,28-dihydroxy-p-tert-butylcalix[4]arene exhibit higher pharmacological activity compared to the starting 7-bromo-5-(o-chloro)phenyl-and 1-hydrazinocarbonylmethyl-7-bromo-5-phenyl-1,2-dihydro-3H-1,4-benzodiazepin-2-ones.

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References

  1. Bogatskii, A.V., Andronati, S.A., and Golovenko, N.Ya., Trankvilizatory (Tranquilizers), Kiev: Naukova Dumka, 1980.

    Google Scholar 

  2. Andronati, S.A., Avrutskii, G.Ya., Bogatskii, A.V., Yakubovskaya, L.N., and Davidenko, T.I., Fenazepam (Phenazepam), Kiev: Naukova Dumka, 1985.

    Google Scholar 

  3. Shapiro, Yu.E., Gorbatyuk, V.Ya., Yakubovskaya, L.N., Andronati, K.S., and Andronati, S.A., Zh. Strukt. Khim., 1996, vol. 37, no. 5, p. 876.

    CAS  Google Scholar 

  4. Da Silva, E., Lazar, A.N., and Coleman, A.W., J. Drug Del. Sci. Technol., 2004, no. 14(1), p. 9.

  5. Antipin, I.S., Stoikov, I.I., Khrustalev, A.A., and Konovalov, A.I., Izv. Ross. Akad. Nauk, Ser. Khim., 2000, no. 11, p. 2038.

  6. Zin’kovskii, V.G., Golovenko, N.Ya., and Bogatskii, A.V., Byull. Eksp. Biol. Med., 1981, no. 1, p. 40.

  7. Golovenko, N.Ya. and Zin’kovskii, V.G., Byull. Eksp. Biol. Med., 1976, no. 9, p. 1078.

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Authors and Affiliations

  1. Bogatskii Physicochemical Institute, National Academy of Sciences of Ukraine, Lyustdorfskaya dor. 86, Odessa, 65080, Ukraine

    E. A. Alekseeva & A. P. Luk’yanenko

  2. Ministry of Education and Science of Ukraine, Mechnikov Odessa National University, Odessa, Ukraine

    I. A. Kravchenko & N. A. Nevarko

Authors
  1. E. A. Alekseeva
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  2. A. P. Luk’yanenko
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  3. I. A. Kravchenko
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  4. N. A. Nevarko
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Correspondence to E. A. Alekseeva.

Additional information

Original Russian Text © E.A. Alekseeva, A.P. Luk’yanenko, I.A. Kravchenko, N.A. Nevarko, 2008, published in Zhurnal Obshchei Khimii, 2008, Vol. 78, No. 5, pp. 806–810.

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Alekseeva, E.A., Luk’yanenko, A.P., Kravchenko, I.A. et al. Preparation and biological properties of inclusion compounds of calix[4]arene and 1,4-benzodiazepinone derivatives. Russ J Gen Chem 78, 949–953 (2008). https://doi.org/10.1134/S1070363208050204

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  • DOI: https://doi.org/10.1134/S1070363208050204

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