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Synthesis of hydrophospohoryl derivatives of the antifungal antibiotic pimaricin by the Kabachnik-Fields reaction

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Abstract

Reactions of the polyene macrolide antibiotic pimaricin with aromatic aldehydes and hypophosphorous acid are shown to afford pimaricin hydrophosphoryl derivatives. Physicochemical and biological properties of these compounds are explored. Biological studies indicated that the pimaricin hydrophosphoryl derivatives are low toxic agents possessing a high antifungal activity.

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Authors and Affiliations

  1. Schulich Faculty of Chemistry, Technion-Israel Institute of Technology, Haifa, 32000, Israel

    V. V. Belakhov

  2. Russian Research Institute of Plant Protection, sh. Podbel’skogo 3, Saint-Petersburg, 196608, Russia

    Yu. D. Shenin

  3. St. Petersburg Technological Institute, Moscovskii pr. 26, St. Petersburg, 198020, Russia

    B. I. Ionin

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  1. V. V. Belakhov
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  2. Yu. D. Shenin
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  3. B. I. Ionin
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Correspondence to V. V. Belakhov.

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Belakhov, V.V., Shenin, Y.D. & Ionin, B.I. Synthesis of hydrophospohoryl derivatives of the antifungal antibiotic pimaricin by the Kabachnik-Fields reaction. Russ J Gen Chem 78, 305–312 (2008). https://doi.org/10.1134/S1070363208020217

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