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Calix[4]arenes containing benzodiazepinone fragments at the lower rim

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Abstract

A series of p-tert-butylcalix[4]arene derivatives containing 1,4(1,5)-benzodiazepinone fragments as substituents were prepared. The biological activity of the compounds, namely, their antispasmodic activity in mice, was evaluated by antagonism with a spasmodic agent, Corazol, upon transdermal administration. According to the data obtained, benzodiazepine derivatives of calixarenes show higher antispasmodic activity compared to 3-hydroxyphenazepam, taking into account their considerably higher molecular weight.

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Authors and Affiliations

  1. Bogatskii Physicochemical Institute, National Academy of Sciences of Ukraine, Lyustdorfskaya doroga 86, Odessa, 65080, Ukraine

    E. A. Alekseeva, K. S. Andronati, A. V. Mazepa, A. I. Gren’ & T. V. Pavlovskaya

  2. Mechnikov Odessa National University, Ministry of Education and Science of Ukraine, Odessa, Ukraine

    I. A. Kravchenko

  3. Dnepropetrovsk National University, Ministry of Education and Science of Ukraine, Dnepropetrovsk, Ukraine

    V. I. Bozhanov

Authors
  1. E. A. Alekseeva
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  2. K. S. Andronati
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  3. A. V. Mazepa
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  4. A. I. Gren’
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  5. T. V. Pavlovskaya
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  6. I. A. Kravchenko
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  7. V. I. Bozhanov
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Additional information

Original Russian Text © E.A. Alekseeva, K.S. Andronati, A.V. Mazepa, A.I. Gren’, T.V. Pavlovskaya, I.A. Kravchenko, V.I. Bozhanov, 2006, published in Zhurnal Obshchei Khimii, 2006, Vol. 76, No. 9, pp. 1527–1530.

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Alekseeva, E.A., Andronati, K.S., Mazepa, A.V. et al. Calix[4]arenes containing benzodiazepinone fragments at the lower rim. Russ J Gen Chem 76, 1464–1467 (2006). https://doi.org/10.1134/S1070363206090180

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  • DOI: https://doi.org/10.1134/S1070363206090180

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