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Delayed Drug Release Films Based on MIL-100(Fe) Metal-Organic Framework

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Abstract

Biocompatible metal-organic framework MIL-100(Fe) was used as a container for a model hydrophobic active pharmaceutical ingredient, ibuprofen, in composite films based on gelatin, pectin, and kappa-carrageenan. According to powder X-ray diffraction and scanning electron microscopy data, the metal-organic framework retained the crystal structure and its particles were uniformly distributed throughout the hydrocolloid matrix. Testing of the obtained film materials under simulated biological conditions using chromatography–mass spectrometry analysis showed that they are applicable as a dosage form for slow release of active pharmaceutical ingredients.

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ACKNOWLEDGMENTS

Elemental analysis was performed using the equipment of the Center for Molecular Structure Investigations of the Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, supported by the Ministry of Science and Higher Education of the Russian Federation (state assignment no. 075-03-2023-642).

Funding

This study was supported by the Russian Science Foundation (grant no. 20-73-10200).

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Authors and Affiliations

  1. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Moscow, Russia

    A. M. Pak & Yu. V. Nelyubina

  2. Moscow Institute of Physics and Technology (National Research University), Moscow, Russia

    A. M. Pak, Yu. V. Nelyubina & V. V. Novikov

  3. Mendeleev University of Chemical Technology of Russia, Moscow, Russia

    T. N. Vol’khina

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  1. A. M. Pak
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  2. T. N. Vol’khina
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  3. Yu. V. Nelyubina
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  4. V. V. Novikov
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Correspondence to V. V. Novikov.

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The authors of this work declare that they have no conflicts of interest.

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Translated by Z. Svitanko

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Pak, A.M., Vol’khina, T.N., Nelyubina, Y.V. et al. Delayed Drug Release Films Based on MIL-100(Fe) Metal-Organic Framework. Russ J Coord Chem 50, 15–20 (2024). https://doi.org/10.1134/S1070328423600900

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  • DOI: https://doi.org/10.1134/S1070328423600900

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