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Complexes of Copper(II) Halides with 2-(3,5-Dimethylpyrazol-1-yl)benzimidazole: Synthesis and Magnetic and Cytotoxic Properties

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Abstract

New coordination compounds of copper(II) halides with 2-(3,5-dimethylpyrazol-1-yl)benzimidazole (L) are synthesized: CuLCl2 (I), [CuL2Cl]Cl⋅H2O⋅C2H5OH (II), and CuLBr2 (III). The compounds are characterized by IR spectroscopy, X-ray diffraction analysis, and static magnetic susceptibility. The crystal structure of compound II is determined by X-ray structure analysis (CIF file CCDC no. 2043452). The cytotoxic properties of ligands L and complexes I and II are studied.

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ACKNOWLEDGMENTS

The authors are grateful to N.P. Korotkevich for obtaining XRD patterns and to I.V. Yushin for recording diffuse reflectance spectra.

Experiments on cytotoxicity tests were carried out on the basis of the Center for Collective Use “Proteomic Analysis” of the Institute of Molecular Biology and Biophysics (Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, Russia).

Funding

This work was supported by the Russian Science Foundation (project no. 20-63-46026) and the Ministry of Science and Higher Education of the Russian Federation (projects nos. 121031700313-8, and 121031700314-5, and FENW-2020-0031 (0852-2020-0031) (state assignment of the Southern Federal University)).

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Authors and Affiliations

  1. Nikolaev Institute of Inorganic Chemistry, Siberian Branch, Russian Academy of Sciences, 630090, Novosibirsk, Russia

    A. D. Ivanova, L. A. Sheludyakova, A. N. Lavrov & L. G. Lavrenova

  2. Research Institute of Physical and Organic Chemistry, Southern Federal University, Rostov-on-Don, Russia

    T. A. Kuz’menko

  3. Novosibirsk State University, 630090, Novosibirsk, Russia

    A. I. Smolentsev & A. S. Bogomyakov

  4. Institute of Molecular Biology and Biophysics, Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, Russia

    L. S. Klyushova

  5. International Tomography Center, Siberian Branch, Russian Academy of Sciences, Novosibirsk, Russia

    A. S. Bogomyakov

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  1. A. D. Ivanova
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  2. T. A. Kuz’menko
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  3. A. I. Smolentsev
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  4. L. A. Sheludyakova
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  5. L. S. Klyushova
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  6. A. S. Bogomyakov
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  7. A. N. Lavrov
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  8. L. G. Lavrenova
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Corresponding author

Correspondence to L. G. Lavrenova.

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The authors declare that they have no conflicts of interest.

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Translated by E. Yablonskaya

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Ivanova, A.D., Kuz’menko, T.A., Smolentsev, A.I. et al. Complexes of Copper(II) Halides with 2-(3,5-Dimethylpyrazol-1-yl)benzimidazole: Synthesis and Magnetic and Cytotoxic Properties. Russ J Coord Chem 47, 751–759 (2021). https://doi.org/10.1134/S1070328421110026

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  • DOI: https://doi.org/10.1134/S1070328421110026

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