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Synthesis, crystal structure and in vitro antitumor activity of a novel organotin(IV) complex with 9-hexyl-9H-carbazole-3-carboxylic acid

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Abstract

9-Hexyl-9H-carbazole-3-carboxylic acid (LCOOH) and its complex with Ph3Sn(OH), [Ph3SnO2CL] (I), were synthesized. The structure of complex I was solved by single-crystal X-ray diffraction determination, indicating that I shows the discrete framework. Furthermore, this complex was tested in vitro for its cytotoxic activity, using human hepatocellular carcinoma cell line (BEL-7402) and human hepatocellular liver carcinoma cell line (HepG2); 5-fluorouracil was used as a positive control substance. This complex showed cytotoxicity greater than that of 5-fluorouracil.

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Authors and Affiliations

  1. Department of Chemistry, Anhui University, and Key Laboratory of Functional Inorganic Materials Chemistry of Anhui Province, Hefei, 230039, P.R. China

    Y. K. Liang & Y. P. Tian

  2. School of Medical Engineering, Hefei University of Technology, Hefei, 230009, P.R. China

    B. F. Ruan

Authors
  1. Y. K. Liang
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  2. B. F. Ruan
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  3. Y. P. Tian
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Correspondence to Y. P. Tian.

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Liang, Y.K., Ruan, B.F. & Tian, Y.P. Synthesis, crystal structure and in vitro antitumor activity of a novel organotin(IV) complex with 9-hexyl-9H-carbazole-3-carboxylic acid. Russ J Coord Chem 38, 396–401 (2012). https://doi.org/10.1134/S1070328412060097

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  • DOI: https://doi.org/10.1134/S1070328412060097

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