Abstract
The work is devoted to the study of the phytochemical composition of subcritical extracts of the underground part of aconite high (Aconitum septentrionale L.). The samples of roots and rhizomes of Aconitum septentrionale grown in the Altai Republic were studied. The quality characteristics of plant biomass were determined: moisture content, ash content, quantitative content of biologically active substances extracted by methods of sequential extraction and sequential processing of plant materials under subcritical conditions. The group composition of biologically active substances of Aconitum septentrionale has been established. The quantitative content of biologically active substances of alkaloid nature isolated from the roots and rhizomes of Aconitum septentrionale by different methods was determined. It is shown that the content of alkaloids extracted under subcritical conditions for 2 h is higher than those extracted by maceration for 16 h. A formulation has been developed to create a cream gel based on extracts of Aconitum septentrionale extracted in various ways. The physico-chemical parameters were analyzed and the effectiveness of cream-gels developed using extracts obtained by various methods from the roots and rhizomes of high aconite was revealed. The data presented in the article are of interest for the creation of biologics based on extracts of Aconitum septentrionale, promising for use in the pharmaceutical industry.
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DATA AVAILABILITY
The data that support the findings of this study are available from the corresponding author upon reasonable request.
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Zakharchenko, A.V., Bazarnova, N.G. & Orlova, A.S. Phytochemical Analysis of Extractive Substances Extracted by Different Methods from the Underground Part of Aconitum Septentrionale L., and the Development of Cream-Gels Based on Them. Russ J Bioorg Chem 49, 1754–1760 (2023). https://doi.org/10.1134/S1068162023070701
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DOI: https://doi.org/10.1134/S1068162023070701