Abstract
Drug delivery systems play a significant role in drug design.They could perform targeted and controlled release over a period, which is appropriate for poorly water-soluble drugs.The purpose of this study is to develop a drug delivery system, consisting of hydroxyapatite (HAp) polymer and sodium alginate (NaAlg), that covers the magnetic core of iron (III) oxide nanoparticles, in order to increases the loading capacity of iron oxide nanoparticles. In this study, iron (III) oxide nanoparticles were prepared by co-precipitation method and coated with HAp and NaAlg. The nanoparticles were characterized by X-ray diffraction, (FTIR), (SEM), and (TEM). Encapsulation efficiency of catechin hydrate (CH) and drug release rate was examined. The assessment of physicochemical characteristics show the synthesis of spherical particles with nanometer size (9–13 nm) and a high encapsulation efficiency (81.25 ± 2.55%) and drug-loading capacity (20.31 ± 0.64%). Maximum drug release obtain at pH = 5.5 coated. Iron (III) oxide show no significant cytotoxic effects. CH-loaded coated IONPs show a higher toxicity against HT-29 and MCF-7 cancer cells compared to free CH. This in vitro study show that the encapsulation of CH, as a potent herbal drug, into IONPs enhances its bioavailability, suggesting the NPs as an efficient vehicle for targeted drug delivery in cancer treatment.
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Authors KS and MN designed the experiments. Authors MN and SF synthesized the nano samples. Authors MN and RM performed cell culture studies and experiments. Authors KS and MN performed biochemical studies. Authors SF, KS, and MN conducted nanotechnology studies. Author SF performed nanoparticle data processing and XRD, FT-IR spectroscopy. Authors RM, KS, and MN performed the cellular and cytotoxic studies. Author RM interpreted the cytotoxic results of the samples. Authors KS and MN contributed to manuscript preparation. All authors participated in the discussion.
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Nobahari, M., Shahanipour, K., Fatahian, S. et al. Evaluation of Cytotoxic Activity of Loaded Catechin into Iron Oxide Nanoparticles Coated with Sodium Alginate and Hydroxyapatite against Human HT-29 Colon Adenocarcinoma and Breast Cancer MCF-7 Cells. Russ J Bioorg Chem 49, 1049–1058 (2023). https://doi.org/10.1134/S1068162023050126
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DOI: https://doi.org/10.1134/S1068162023050126