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The Effect of Sitagliptin and Exenatide on Insulin, Insulin Receptor and Insulin Receptor Substrate Gene Expression in Diabetic Rats

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Abstract

Diabetes mellitus is a chronic metabolic disorder characterized by persistent hyperglycemia that results from abnormal secretion of insulin, inappropriate action of insulin or both. The aim of this study is to determine the effects of exenatide and sitagliptin treatment on the expression of insulin (INS-1), insulin receptor (INSR) and insulin receptor substrate (IRS-1) genes. In this study streptozotocin-induced diabetic rats were treated with sitagliptin (10 mg/kg) and exenatide (0.1 µg/kg) for 15 days. We measured INS-1, INSR and IRS-1 gene expression levels and examined the histology of pancreatic tissues in all groups. Exenatide and sitagliptin treatment increased gene expression levels of INS-1, INSR and IRS-1.

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Funding

This study was supported by funding from the Mersin University Scientific Research Projects (Project no. 2017-2-AP3-2532), Mersin, Turkey.

Author information

Authors and Affiliations

  1. Department of Pharmacy Services, Vocational School of Health Services, Tarsus University, Mersin, Turkey

    M. Yildirim

  2. Department of Pathology, Osmaniye Public Hospital, Osmaniye, Turkey

    O. Agtas Mistik

  3. Department of Biochemistry, Faculty of Pharmacy, Mersin University, Mersin, Turkey

    A. E. Yalin & S. Yalin

  4. Department of Biophysics, Faculty of Medicine, Mersin University, Mersin, Turkey

    U. Comelekoglu

  5. Department of Biochemistry, Faculty of Pharmacy, Van Yuzuncu yil University, Van, Turkey

    M. Berkoz

  6. Department of Pathology, Faculty of Medicine, Mersin University, Mersin, Turkey

    R. Bozdogan Arpaci

Authors
  1. M. Yildirim
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Correspondence to M. Yildirim.

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Conflict of interest. The authors declare that they have no conflicts of interest.

Statement on the welfare of animals. Ethics Committee Certificate of Approval was obtained from Mersin University Local Ethics Committee for Animal Experiments (HADYEK).

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Yildirim, M., Mistik, O.A., Yalin, A.E. et al. The Effect of Sitagliptin and Exenatide on Insulin, Insulin Receptor and Insulin Receptor Substrate Gene Expression in Diabetic Rats. Russ J Bioorg Chem 49, 610–615 (2023). https://doi.org/10.1134/S1068162023030275

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  • DOI: https://doi.org/10.1134/S1068162023030275

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