Skip to main content

Advertisement

SpringerLink
Log in

Anti-Influenza Activity of Extracts from Plants of the Lamiaceae Family

  • Published:
Russian Journal of Bioorganic Chemistry Aims and scope Submit manuscript

Abstract

We have demonstrated that the water and ethanol extracts of the Nepeta cataria, Nepeta sibirica, Scutellaria baicalensis, Hyssopus officinalis, and Betonica officinalis plants, water extracts of Dracocephalum moldavica, Glechoma hederacea, Mentha arvensis, Prunella vulgaris, and Melissa officinalis, and ethanol extracts of Mentha piperita, Mentha crispa, Origanum vulgare, Hyssopus officinalis, and Salvia verticillata showed antiviral activity against the influenza virus subtype H5N1. The water extracts of Nepeta cataria and Glechoma hederacea showed the highest antiviral effect against the H5N1 subtype (NI 3.75). The water and ethanol extracts of Scutellaria baicalensis, Mentha piperita, Mentha arvensis, and Mentha crispa, water extract of Dracocephalum moldavica, and ethanol extracts of Glechoma hederacea, Origanum vulgare, Prunella vulgaris, Hyssopus officinalis, Betonica officinalis, and Salvia verticillata have shown to exhibit the antiviral activity against influenza virus subtype H3N2. The ethanol extract of Betonica officinalis showed the highest virus neutralizing activity against the H3N2 subtype (NI 4.25). The chemical analysis of the aerial parts of plants of the Lamiaceae family has shown that Dracocephalum nutans contains the highest amount of flavonols (4.47 ± 0.04%); the highest content of tannins has been found in Mentha arvensis (17.62 ± 0.78%), and the highest content of catechins has been found in Nepeta cataria (0.43 ± 0.007%). Thus, the plant extracts of the Lamiaceae family are promising sources for further studies to develop new antiviral drugs.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1.
Fig. 2.
Fig. 3.

Similar content being viewed by others

REFERENCES

  1. World Health Organization, Influenza Fact Sheet, March 2018. www.who.int/ru/news-room/fact-sheets/ detail/influenza-%28seasonal%29.

  2. Ershov, F.I. and Romantsev, M.G., Lekarstvennye sredstva, primenyaemye pri virusnykh zabolevaniyakh (Medicines Used in Viral Diseases), Moscow, 2007.

    Google Scholar 

  3. Li, K.S., Guan, Y., Wang, J., Smith, G.J.D., Xu, K.M., Duan, L., Rahardjo, A.P., Puthavathana, P., Buranathai, C., Nguyen, T.D., Estoepangestle, A.T.S., Chaisingh, A., Auewarakul, P., Long, H.T., Hanh, N.T.H., Webby, R.J., Poon, L.L.M., Chen, H., Shortridge, K.F., Yuen, K.Y., Webster, R.G., and Peiris, J.S.M., Genesis of a highly pathogenic and potentially pandemic H5N1 influenza virus in Eastern Asia, Nature (London, U.K.), 2004, vol. 430, no. 6996, pp. 209–213. https://doi.org/10.1038/nature02746

    Article  CAS  Google Scholar 

  4. Watts, J., Asian nations step up action to curb spread of avian influenza, Lancet, 2004, vol. 363, no. 9406, p. 373. https://doi.org/10.1016/S0140-6736(04)15475-5

    Article  Google Scholar 

  5. Abad, M.J., Guerra, J.A., Bermejo, P., Irurzun, A., and Carrasco, L., Search for antiviral activity in higher plant extracts, Phytother. Res., 2000, vol. 14, no. 8, pp. 604–607. https://doi.org/10.1002/1099-1573(200012)14:8<604::aid-ptr678>3.0.co;2-l

    Article  CAS  Google Scholar 

  6. Singh, P., Chakraborty, P., He, D.H., and Mergia, A., Extract prepared from the leaves of Ocimum basilicum inhibits the entry of Zika virus, Acta Virol., 2019, vol. 63, no. 3, pp. 316–321. https://doi.org/10.4149/av_2019_307

    Article  CAS  Google Scholar 

  7. Tan, Y.P., Houston, S.D., Modhiran, N., Savchenko, A.I., Boyle, G.M., Young, P.R., Watterson, D., and Williams, C.M., Stachyonic acid: A dengue virus inhibitor from Basilicum polystachyon, Chemistry, 2019, vol. 25, no. 22, pp. 5664–5667. https://doi.org/10.1002/chem.201900591

    Article  CAS  Google Scholar 

  8. Li, Y., Liu, Y., Ma, A., Bao, Y., Wang, M., and Sun, Z., In vitro antiviral, anti-inflammatory, and antioxidant activities of the ethanol extract of Mentha piperita L., Food Sci. Biotechnol., 2017, vol. 26, no. 6, pp. 1675–1683. https://doi.org/10.1007/s10068-017-0217-9

    Article  CAS  Google Scholar 

  9. Yin, Z.K., Feng, Z.M., Jiang, J.S., Zhang, X., Zhang, P.C., and Yang, Y.N., Two new tanshinone derivatives from the rhizomes of Salvia miltiorrhiza and their antiviral activities, J. Asian Nat. Prod. Res., 2020, vol. 22, no. 1, pp. 24–29. https://doi.org/10.1080/10286020.2019.1645132

    Article  CAS  Google Scholar 

  10. Zhang, D., Guo, J., Zhang, M., Liu, X., Ba, M., Tao, X., Yu, L., Guo, Y., and Dai, J., Oxazole-containing diterpenoids from cell cultures of Salvia miltiorrhiza and their anti-HIV-1 activities, J. Nat. Prod., 2017, vol. 80, no. 12, pp. 3241–3246. https://doi.org/10.1021/acs.jnatprod.7b00659

    Article  CAS  Google Scholar 

  11. Rastitel’nye resursy Rossii: Dikorastushchie tsvetkovye rasteniya, ikh komponentnyi sostav i biologicheskaya aktivnost'. T. 4. Semeistva Caprifoliaceae—Lobeliaceae (Plant Resources of Russia: Wild Flowering Plants, their Composition and Biological Activity, vol. 4: Caprifoliaceae—Lobeliaceae Families), St. Petersburg, 2011.

  12. Astani, A., Reichling, J., and Schnitzler, P., Melissa officinalis extract inhibits attachment of herpes simplex virus in vitro, Chemotherapy, 2012, vol. 58, no. 1, pp. 70–77. https://doi.org/10.1159/000335590

    Article  CAS  Google Scholar 

  13. Li, R. and Wang, L., Baicalin inhibits influenza virus a replication via activation of type I IFN signaling by reducing miR-146a, Mol. Med. Rep., 2019, vol. 20, no. 6, pp. 5041–5049. https://doi.org/10.3892/mmr.2019.10743

    Article  CAS  Google Scholar 

  14. Protsenko, M.A., Development of technology for experimental samples of preparations from higher basidiomycetes, Cand. Sci. (Biol.) Dissertation, Kol’tsovo, 2016.

  15. Belikov, V.V., and Shraiber, M.S., Methods for the analysis of flavonoid compounds, Farmatsiya, 1970, no. 1, pp. 66–72.

  16. Kukushkina, T.A., Zykov, A.A., and Obukhova, L.A., Common cuff (Alchemilla vulgaris L.) as a source of medicines, in Aktual’nye problemy sozdaniya novykh lekarstvennykh preparatov prirodnogo proiskhozhdeniya: materialy VII Mezhdunarodnogo S’ezda (Actual Problems of Creating New Drugs of Natural Origin, Proceedings of the 7th International Congress), St. Petersburg, 2003, pp. 64–69.

  17. Fedoseeva, L.M., Study of tannins of underground and aboveground organs of the thick-leaved bergenia (Bergenia crassifolia (L.) Fitsch.) growing in Altai, Khim. Rastit. Syr’ya, 2005, no. 2, pp. 45–50.

  18. Zaks, L., Statisticheskoe otsenivanie (Statistical Estimation), Moscow, 1976.

    Google Scholar 

  19. Khalafyan, A.A., Statistica 6. Statisticheskii analiz dannykh (Statistica 6. Statistical Data Analysis), 2nd ed., Moscow, 2010.

  20. Khabriev, R.U., Rukovodstvo po eksperimental’nomu (doklinicheskomu) izucheniyu novykh farmakologicheskikh veshchestv: spravochnik (Guidelines for the Experimental (Preclinical) Study of New Pharmacological Substances), 2nd ed., Moscow, 2005.

Download references

Funding

The work was supported by the State program of the State Research Center of Virology and Biotechnology Vector.

Author information

Authors and Affiliations

  1. State Research Center of Virology and Biotechnology Vector, 630559, Koltsovo, Novosibirsk oblast, Russia

    M. A. Protsenko, N. A. Mazurkova & E. I. Filippova

  2. Central Siberian Botanical Garden, Siberian Branch, Russian Academy of Sciences, 630090, Novosibirsk, Russia

    T. A. Kukushkina, I. E. Lobanova, Yu. A. Pshenichkina & G. I. Vysochina

Authors
  1. M. A. Protsenko
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. N. A. Mazurkova
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. E. I. Filippova
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. T. A. Kukushkina
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. I. E. Lobanova
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Yu. A. Pshenichkina
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. G. I. Vysochina
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to M. A. Protsenko.

Ethics declarations

The authors declare that they have no conflicts of interest. This article does not contain any studies involving animals or human participants performed by any of the authors.

Additional information

Translated by A. S. Levina

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Protsenko, M.A., Mazurkova, N.A., Filippova, E.I. et al. Anti-Influenza Activity of Extracts from Plants of the Lamiaceae Family. Russ J Bioorg Chem 48, 1534–1541 (2022). https://doi.org/10.1134/S1068162022070238

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S1068162022070238

Keywords:

Search

Navigation