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Anti-Inflammatory Effects of Coumarin–Selenophene Derivatives on LPS-Stimulated RAW 264.7 Macrophage Cells

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Abstract

Coumarin and coumarin derivatives have been known for their anti-viral, anti-oxidant, anti-cancer and anti-inflammatory activities. Changes in biological activity when these biologically active compounds are combined with different heterocyclic groups are among the topics of interest to researchers in recent years. Therefore, a series of coumarin–selenophene hybrid compounds have been synthesized. Products are fully characterized by NMR and FT-IR spectroscopic techniques. The prepared compounds are screened for their anti-inflammatory potencies on LPS induced mouse macrophage cell line (RAW 264.7). The results showed that coumarin–selenophene hybrid compounds were not cytotoxic at the tested concentrations on RAW 264.7 macrophages. Also, these compounds decreased TNF- α, IL-6 secretion, and NO, PGE2 production in dose-depended manner. According to our results, coumarin–selenophene hybrid compounds have the capacity to moderate the immune response and a potential anti-inflammatory activity.

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Funding

The research leading to these results received funding from (Scientific Research Committee of Mersin University) under Grant Agreement no. 2021-1-AP4-4227.

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Authors and Affiliations

  1. Institute of Biopharmaceutics and Pharmaceutical Technology, University of Saarland, Saarbrücken, Germany

    M. Yildirim

  2. Deparment of Pharmacy Services, Vocational School of Health Services, Tarsus University, Mersin, Turkey

    M. Yildirim

  3. Deparment of Biochemistry, Faculty of Pharmacy, Mersin University, Mersin, Turkey

    Z. N. Unal

  4. Department of Chemistry, Arts and Science Faculty, Cukurova University, Adana, Turkey

    M. Ersatir & E. S. Giray

  5. Advanced Technology Education Research and Application Center, Mersin University, Mersin, Turkey

    D. Yetkin

  6. Department of Biochemistry, Faculty of Pharmacy, Harran University, Sanlıurfa, Turkey

    U. Degirmenci

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  1. M. Yildirim
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Correspondence to M. Yildirim.

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Yildirim, M., Unal, Z.N., Ersatir, M. et al. Anti-Inflammatory Effects of Coumarin–Selenophene Derivatives on LPS-Stimulated RAW 264.7 Macrophage Cells. Russ J Bioorg Chem 48, 1209–1214 (2022). https://doi.org/10.1134/S1068162022060279

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  • DOI: https://doi.org/10.1134/S1068162022060279

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